Literature DB >> 6856034

Dose and time dependent effects of morphine on the incorporation of [3H]valine into soluble brain and liver proteins.

L Rönnbäck, E Hansson, A Cupello.   

Abstract

Morphine (10(-6)-10(-5) M) causes an increase in incorporation of [3H]valine into soluble proteins during 4 hr in rat brain cortical slices, liver slices and cultivated astroglial cells. The effects are dose-dependent. They are neither cell specific nor strictly related to classical opiate receptors. Pulse-labeling with [3H]valine for 60 min after incubation in 10(-6)-10(-5) M morphine, resolves time-dependent changes in incorporation, with both increases and decreases in protein metabolism.

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Year:  1983        PMID： 6856034     DOI： 10.1007/bf00965725

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  29 in total

1.  Kinetic analysis of phenylalanine-induced inhibition in the saturable influx of tyrosine, tryptophan, leucine and histidine into brain cortex slices from adult and 7-day-old rats.

Authors:  M L Vahvelainen; S S Oja
Journal:  J Neurochem       Date:  1975-05       Impact factor: 5.372

Review 2.  Influence of morphine on membrane turnover and function.

Authors:  R Hitzemann; R Natsuki; Y Ohizumi; D Johnson; H Loh
Journal:  Adv Biochem Psychopharmacol       Date:  1979

3.  Stabilization of brain free polysomes by morphine.

Authors:  S Stolman; H H Loh
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1975-11

4.  Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures.

Authors:  J Booher; M Sensenbrenner
Journal:  Neurobiology       Date:  1972

5.  The mode of action of levallorphan as an inhibitor of cell growth.

Authors:  R Greene; B Magasanik
Journal:  Mol Pharmacol       Date:  1967-09       Impact factor: 4.436

6.  Measurements of rates of protein synthesis in rat brain slices.

Authors:  D S Dunlop; W Van Elden; A Lajtha
Journal:  J Neurochem       Date:  1974-05       Impact factor: 5.372

7.  The effect of morphine administration on the incorporation of [14-C]leucine into protein in cell-free systems from rat brain and liver.

Authors:  D H Clouet; M Ratner
Journal:  J Neurochem       Date:  1968-01       Impact factor: 5.372

8.  The effect of the administration of morphine on the incorporation of [14C]leucine into the proteins of rat brain in vivo.

Authors:  D H Clouet; M Ratner
Journal:  Brain Res       Date:  1967-02       Impact factor: 3.252

9.  Assessment of protein turnover in perfused rat liver. Evidence for amino acid compartmentation from differential labeling of free and tRNA-gound valine.

Authors:  E A Khairallah; G E Mortimore
Journal:  J Biol Chem       Date:  1976-03-10       Impact factor: 5.157

10.  Inhibition of the development of tolerance to morphine in rats by drugs which inhibit ribonucleic acid or protein synthesis.

Authors:  B M Cox; O H Osman
Journal:  Br J Pharmacol       Date:  1970-01       Impact factor: 8.739
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  1 in total

1.  Macromolecular changes in brain stem of morphinized rats.

Authors:  L Rönnbäck; C Wikkelsø; C Blomstrand
Journal:  Neurochem Res       Date:  1983-11       Impact factor: 3.996
  1 in total

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