Literature DB >> 6855792

An application of Acridine Orange fluorescent staining to the micronucleus test.

M Hayashi, T Sofuni, M Ishidate.   

Abstract

Acridine Orange fluorescent staining was applied to the micronucleus test in mice and rats. Micronuclei emitted bright green fluorescence and were easily distinguished from micronucleus-like inclusions or contaminants. In rat bone-marrow cells, micronuclei with green fluorescence could be easily distinguished from granules accidentally dispersed from broken mast cells, which showed bright red fluorescence. Therefore, it is recommended that the Acridine Orange staining method be used to provide more reliable data in the micronucleus test.

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Year:  1983        PMID： 6855792     DOI： 10.1016/0165-7992(83)90096-9

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  31 in total

1.  Cytogenetic damage induced by folate deficiency in mice is enhanced by caffeine.

Authors:  J T MacGregor; R Schlegel; C M Wehr; P Alperin; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

2.  A systematic assessment of genotoxicity on pivaloylacylation-7ADCA-a wide existing antibiotic impurity.

Authors:  Qingying Luo; Yang Li; Zunzhen Zhang
Journal:  Int J Clin Exp Med       Date:  2014-11-15

3.  Response kinetics of radiation-induced micronucleated reticulocytes in human bone marrow culture.

Authors:  Hongliang Sun; Ying Tsai; Irena Nowak; Stephen D Dertinger; J H David Wu; Yuhchyau Chen
Journal:  Mutat Res       Date:  2010-11-04       Impact factor: 2.433

4.  Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage.

Authors:  B C Blount; M M Mack; C M Wehr; J T MacGregor; R A Hiatt; G Wang; S N Wickramasinghe; R B Everson; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

5.  Use of comet and micronucleus assays to measure genotoxicity in meadow voles (Microtus pennsylvanicus) living in golf course ecosystems exposed to pesticides.

Authors:  Loren D Knopper; Pierre Mineau; James P McNamee; David R S Lean
Journal:  Ecotoxicology       Date:  2005-04       Impact factor: 2.823

6.  Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitro.

Authors:  Hongliang Sun; Stephen D Dertinger; Ollivier Hyrien; J H David Wu; Yuhchyau Chen
Journal:  Mutat Res       Date:  2009-09-26       Impact factor: 2.433

7.  Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotropin-releasing hormone receptor antagonist.

Authors:  Thomas L Horn; J Brooks Harder; William D Johnson; Patrick T Curry; Ralph E Parchment; Robert L Morrissey; Paul W Mellick; Karim A Calis; Philip W Gold; Kenner C Rice; Carlo Contoreggi; Dennis S Charney; Giovanni Cizza; Elizabeth R Glaze; Joseph E Tomaszewski; David L McCormick
Journal:  Toxicology       Date:  2008-03-13       Impact factor: 4.221

8.  Detection of mitomycin C-induced testicular toxicity by micronucleus assay in mice.

Authors:  Soichi Nakagawa; Chisato Mori
Journal:  Reprod Med Biol       Date:  2003-04-30

9.  Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals.

Authors:  Kristine L Witt; Elizabeth Livanos; Grace E Kissling; Dorothea K Torous; William Caspary; Raymond R Tice; Leslie Recio
Journal:  Mutat Res       Date:  2007-08-11       Impact factor: 2.433

10.  Protective effect of melatonin against mitomycin C-induced genotoxic damage in peripheral blood of rats.

Authors:  S Ortega-Gutiérrez; M López-Vicente; F Lostalé; L Fuentes-Broto; E Martínez-Ballarín; J J García
Journal:  J Biomed Biotechnol       Date:  2009-10-20
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