| Literature DB >> 6854583 |
D M Stout, W L Matier, C Barcelon-Yang, R D Reynolds, B S Brown.
Abstract
Twenty-four structural derivatives of the antiarrhythmic drug changrolin were synthesized and tested for antiarrhythmic and parasympatholytic activities. It was found that while the bis(pyrrolidinylmethyl)phenol pattern of changrolin appeared to be optimal in this series, a wide latitude existed for the heteroaryl substituent for maintaining good antiarrhythmic activity. Further, the antiarrhythmic and parasympatholytic activities tended to exhibit parallel changes.Entities:
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Year: 1983 PMID： 6854583 DOI： 10.1021/jm00360a005
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446