Literature DB >> 6853590

Identification of three indolic compounds in a pigmented-melanoma cell-culture supernatant by gas chromatography-mass spectrometry.

S Pavel, F A Muskiet, L de Ley, T H The, W van der Slik.   

Abstract

In the supernatant of melanoma cell culture SK mel 25 three indolic compounds - 5-hydroxy-6-methoxyindole, 5-hydroxy-6-methoxyindolyl-2-carboxylic, and 6-hydroxy-5-methoxyindolyl-2-carboxylic acids - have been identified. The supernatants were extracted with ethyl acetate, derivatized, and analyzed by gas chromatography-mass spectrometry. The significance of this finding is discussed.

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Year:  1983        PMID： 6853590     DOI： 10.1007/bf00395758

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  9 in total

1.  O-Methylation in the conversion of tyrosine to melanin.

Authors:  J AXELROD; A B LERNER
Journal:  Biochim Biophys Acta       Date:  1963-06-04

2.  DOPA decarboxylase activity in a transplantable hamster melanoma.

Authors:  R Håkanson; H Möller; N G Stormby
Journal:  Experientia       Date:  1965-05-15

Review 3.  Recent advances in the chemistry of melanogenesis in mammals.

Authors:  G Prota
Journal:  J Invest Dermatol       Date:  1980-07       Impact factor: 8.551

4.  An experimental approach to the chemotherapy of melanoma.

Authors:  M M Wick
Journal:  J Invest Dermatol       Date:  1980-02       Impact factor: 8.551

5.  Identification of two Thormählen-positive compounds from melanotic urine by gas chromatography-mass spectrometry.

Authors:  S Pavel; F A Muskiet; G T Nagel; Z Schwippelová; J Duchon
Journal:  J Chromatogr       Date:  1981-03-13

6.  5,6-Dihydroxyindole is a melanin precursor showing potent cytotoxicity.

Authors:  J M Pawelek; A B Lerner
Journal:  Nature       Date:  1978-12-07       Impact factor: 49.962

7.  Identification of two new metabolites in melanoma urine: 5-hydroxy-6-methoxyindole-2-carboxylic and 5-methoxy-6-hydroxyindole-2-carboxylic acids.

Authors:  J Duchon; B Matous
Journal:  Clin Chim Acta       Date:  1967-06       Impact factor: 3.786

8.  Eumelanin (precursor) metabolites as markers for pigmented malignant melanoma: a preliminary report.

Authors:  S Pavel; F A Muskiet
Journal:  Cancer Detect Prev       Date:  1983

9.  A qualitative gas chromatographic analysis of substituted 5,6-dihydroxyindoles from the urine of patients with melanoma.

Authors:  S Pavel; F A Muskiet; A Budesínská; J Duchon
Journal:  Tumori       Date:  1981-08
  9 in total
  5 in total

Review 1.  Sunlight, melanogenesis and radicals in the skin.

Authors:  M R Chedekel; L Zeise
Journal:  Lipids       Date:  1988-06       Impact factor: 1.880

2.  Catechol-O-methyltransferase in vitiligo.

Authors:  I C Le Poole; R M van den Wijngaard; N P Smit; J Oosting; W Westerhof; S Pavel
Journal:  Arch Dermatol Res       Date:  1994       Impact factor: 3.017

3.  Identification of Thormählen-positive compound "B" in urine of patients with malignant melanoma.

Authors:  S Pavel; R Boverhof; W van der Slik
Journal:  Arch Dermatol Res       Date:  1984       Impact factor: 3.017

4.  ASSESSMENT OF MC1R AND α-MSH GENE SEQUENCES IN IRANIAN VITILIGO PATIENTS.

Authors:  M Eskandani; S Hasannia; S Vandghanooni; N Pirooznia; J Golchai
Journal:  Indian J Dermatol       Date:  2010-10       Impact factor: 1.494

5.  Analysis of oxidative stress status, catalase and catechol-O-methyltransferase polymorphisms in Egyptian vitiligo patients.

Authors:  Dina A Mehaney; Hebatallah A Darwish; Rehab A Hegazy; Mohammed M Nooh; Amira M Tawdy; Heba I Gawdat; Maha M El-Sawalhi
Journal:  PLoS One       Date:  2014-06-10       Impact factor: 3.240
  5 in total

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