Necrotizing pseudolymphomatous lymphadenitis and rapidly fatal lymphoma in Okinawa.

Thirty-one cases of a peculiar lymphadenitis with pathognomonic necrosis and prominent infiltration with immunoblasts were studied together with 36 cases of a rapidly fatal lymphoma of distinctive morphological pattern and characterized by massive coagulative necrosis. These cases all occurred on the island of Okinawa, and the lesions have not, to our knowledge, been reported previously. This further example of a type of geographically confined lymph nodal disease may, on further study yield insights into pathogenetic mechanisms in lymphomas. Further studies should include cell marker and virological investigations, which were not available to us at the time of the study.