Literature DB >> 6852251

Hemoglobin Okayama [beta 2 (NA 2) His replaced by Gln]: a new 'silent' hemoglobin variant with substituted amino acid residue at the 2,3-diphosphoglycerate binding site.

T Harano, K Harano, S Shibata, S Ueda, H Mori, N Arimasa.   

Abstract

A new 'silent' abnormal hemoglobin, Hb Okayama [beta 2 (NA 2) His replaced by Gln], happened to be discovered in a diabetic Japanese female living in Okayama Prefecture, Japan, in the course of glyco-Hb measurement of the blood samples of diabetic patients. This variant did not differ from Hb A by conventional electrophoretic tests. Only the isoelectric focusing on PAG plate for the determination of glyco-Hb and the cation exchanger chromatography were successful in the separation of this abnormal variant from Hb A and glyco-Hb. Functional study of the whole blood demonstrated a slight increase of oxygen affinity.

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Year:  1983        PMID： 6852251     DOI： 10.1016/0014-5793(83)80239-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Amino-terminal processing of proteins: hemoglobin South Florida, a variant with retention of initiator methionine and N alpha-acetylation.

Authors:  J P Boissel; T J Kasper; S C Shah; J I Malone; H F Bunn
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

2.  Haemoglobin Graz, a novel haemoglobin variant.

Authors:  W J Schnedl; E C Reisinger; T R Pieber; M Neubauer; E Balaun; G J Krejs; P Hopmeier
Journal:  Diabetologia       Date:  1995-01       Impact factor: 10.122

3.  Hb Long Island: a hemoglobin variant with a methionyl extension at the NH2 terminus and a prolyl substitution for the normal histidyl residue 2 of the beta chain.

Authors:  R C Barwick; R T Jones; C G Head; M F Shih; J T Prchal; D T Shih
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

Review 4.  Hemoglobin variants recently detected in Austria.

Authors:  W J Schnedl; E C Reisinger; R W Lipp; G J Krejs; P Hopmeier
Journal:  Ann Hematol       Date:  1995-10       Impact factor: 3.673

5.  Identification of the First Japanese Family Harboring a Novel Hemoglobin Variant "Perpignan", Which Caused Low HbA1c Measurement During Diabetic Follow-Up.

Authors:  Mami Nakamura; Ayako Miyazaki; Takayuki Takubo; Yoko Matsuzawa; Jun Saito; Masao Omura; Tetsuo Nishikawa
Journal:  Jpn Clin Med       Date:  2011-02-02

6.  Evolutionary Genetics of Hypoxia Tolerance in Cetaceans during Diving.

Authors:  Ran Tian; Zhengfei Wang; Xu Niu; Kaiya Zhou; Shixia Xu; Guang Yang
Journal:  Genome Biol Evol       Date:  2016-02-24       Impact factor: 3.416
  6 in total

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