Literature DB >> 6852013

Destruction of phospholipids and respiratory-chain activity in pig-heart submitochondrial particles induced by an adriamycin-iron complex.

E J Demant, P K Jensen.   

Abstract

Ferric ion complexes of the antibiotic and antitumor agent adriamycin support peroxidation of phospholipids in pig heart submitochondrial particles as judged by disappearance of polyunsaturated fatty acids, loss in extractable phospholipid, adriamycin-Fe3+-dependent oxygen consumption and formation of material with ultraviolet absorption. Peroxidation was stimulated to an extent of about 100% at low rates of NADH oxidation in the submitochondrial particles, whereas oxidation rates higher than 50 nmol NADH oxidized x min-1 x mg protein-1 appeared to protect the membrane lipids. NADH oxidase, NADH-cytochrome c reductase as well as cytochrome c oxidase activities in the submitochondrial particles were progressively inactivated during incubation with adriamycin in the presence of Fe3+ ions, whereas NADH-ferricyanide reductase activity remained fully stable.

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Year:  1983        PMID： 6852013     DOI： 10.1111/j.1432-1033.1983.tb07397.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  12 in total

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Authors:  K Saito; K Takeda; S Okamoto; R Okamoto; K Makino; Y Tameda; Y Nomura; H Maeda; T Ichihara; T Nakano
Journal:  J Nucl Cardiol       Date:  2000 Nov-Dec       Impact factor: 5.952

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Authors:  N C Robinson
Journal:  J Bioenerg Biomembr       Date:  1993-04       Impact factor: 2.945

3.  The one-ring open hydrolysis product intermediates of the cardioprotective agent ICRF-187 (dexrazoxane) displace iron from iron-anthracycline complexes.

Authors:  J L Buss; B B Hasinoff
Journal:  Agents Actions       Date:  1993-09

4.  Transmembrane distribution of lipophilic cations in response to an electrochemical potential in reconstituted cytochrome c oxidase vesicles and in vesicles exhibiting a potassium ion diffusion potential.

Authors:  T D Madden; T E Redelmeier
Journal:  J Bioenerg Biomembr       Date:  1994-04       Impact factor: 2.945

5.  The specificity of anti-cardiolipin antibodies from syphilis patients and from patients with systemic lupus erythematosus.

Authors:  S Mouritsen; M Høier-Madsen; A Wiik; O Orum; N Strandberg Pedersen
Journal:  Clin Exp Immunol       Date:  1989-05       Impact factor: 4.330

6.  Similar changes in cardiac morphology and DNA synthesis induced by doxorubicin and 4'-epi-doxorubicin.

Authors:  K Wassermann; K Mølgaard; E Steiness
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

7.  The removal of metal ions from transferrin, ferritin and ceruloplasmin by the cardioprotective agent ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] and its hydrolysis product ADR-925.

Authors:  B B Hasinoff; S V Kala
Journal:  Agents Actions       Date:  1993-05

8.  Inhibition and inactivation of NADH-cytochrome c reductase activity of bovine heart submitochondrial particles by the iron(III)-adriamycin complex.

Authors:  B B Hasinoff
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

9.  Comparison of the protective effects of desferrioxamine and ICRF-187 against doxorubicin-induced toxicity in spontaneously hypertensive rats.

Authors:  E H Herman; J Zhang; V J Ferrans
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

10.  The iron(III)-adriamycin complex inhibits cytochrome c oxidase before its inactivation.

Authors:  B B Hasinoff; J P Davey
Journal:  Biochem J       Date:  1988-03-15       Impact factor: 3.857
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