Literature DB >> 6849795

The mode of action of cis dichloro-bis (isopropylamine) trans dihydroxy platinum IV (CHIP) studied by the analysis of chromosome aberration production.

E Bocian, M Laverick, A H Nias.   

Abstract

The induction of chromosome damage by the Platinum complex CHIP in Chinese hamster ovary (CHO) cells has been studied, together with the relationship between cell survival and aberration frequency. The type and frequency of chromosome aberrations observed in asynchronous and G1 phase treated cells indicated a similar mode of action to that of bifunctional alkylating agents. A log-linear relationship was observed between the frequency of chromatid aberrations (excluding gaps) and the level of survival after CHIP treatment, with approximately one aberration per cell corresponding to 37% survival.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6849795      PMCID： PMC2011329          DOI： 10.1038/bjc.1983.80

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  16 in total

1.  An analysis of the interaction of a platinum complex and radiation with CHO cells using the molecular theory of cell survival.

Authors:  K H Chadwick; H P Leenhouts; I Szumiel; A H Nias
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1976-12

2.  Growth and nucleic acid synthesis in synchronously dividing populations of HeLa cells.

Authors:  T TERASIMA; L J TOLMACH
Journal:  Exp Cell Res       Date:  1963-04       Impact factor: 3.905

3.  Cross-linking of complementary strands of DNA in mammalian cells by antitumour platinum compounds.

Authors:  J J Roberts; J M Pascoe
Journal:  Nature       Date:  1972-02-04       Impact factor: 49.962

4.  The relationship between chromosomal aberrations, survival and DNA repair in tumour cell lines of differential sensitivity to X-rays and sulphur mustard.

Authors:  D Scott; M Fox; B W Fox
Journal:  Mutat Res       Date:  1974-02       Impact factor: 2.433

5.  Mechanisms of chromosomal aberration production. I. Aberration induction by ultraviolet light.

Authors:  M A Bender; H G Griggs; P L Walker
Journal:  Mutat Res       Date:  1973-12       Impact factor: 2.433

Review 6.  Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation.

Authors:  M A Bender; H G Griggs; J S Bedford
Journal:  Mutat Res       Date:  1974-05       Impact factor: 2.433

7.  Premature chromosome condensation. II. The nature of chromosome gaps produced by alkylating agents and ultraviolet light.

Authors:  W N Hittelman; P N Rao
Journal:  Mutat Res       Date:  1974-05       Impact factor: 2.433

8.  Endoreduplication in cultured mammalian cells treated with 4-nitroquinoline I-oxide.

Authors:  S Sutou
Journal:  Mutat Res       Date:  1973-05       Impact factor: 2.433

9.  Action of a platinum complex [cis-dichlorobis (cyclopentylamine)-platinum (II)] on Chinese hamster ovary cells in vitro.

Authors:  I Szumiel; A H Nias
Journal:  Chem Biol Interact       Date:  1976-08       Impact factor: 5.192

10.  Post-replication repair of DNA in Chinese hamster cells treated with cis platinum (II) diamine dichloride. Enhancement of toxicity and chromosome damage by caffeine.

Authors:  H W Van Den Berg; J J Roberts
Journal:  Mutat Res       Date:  1975-12       Impact factor: 2.433
View more
  4 in total

1.  Evaluation of CHIP (iproplatin) in recurrent pediatric malignant solid tumors. A phase II study (Pediatric Oncology Group).

Authors:  R Nitschke; C Pratt; M Harris; J Krischer; T J Vietti; H Grier; W Kamps; S Toledano
Journal:  Invest New Drugs       Date:  1992-07       Impact factor: 3.850

2.  Evaluation of trans-tetrachloro-1,2-diaminocyclohexane platinum (IV) in murine leukemia L1210 resistant and sensitive to cis-diamminedichloroplatinum (II).

Authors:  L J Wilkoff; E A Dulmadge; M W Trader; S D Harrison; D P Griswold
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

Review 3.  Advances in platinum cancer chemotherapy. Advances in the design of cisplatin analogues.

Authors:  P C Hydes; M J Russell
Journal:  Cancer Metastasis Rev       Date:  1988-04       Impact factor: 9.264

4.  Sister chromatid exchanges induced by two radiosensitizing platinum compounds (cis-dichloro-bis isopropylamine trans dihydroxy platinum IV (CHIP) and cis platinum metronidazole2Cl2(FLAP)) in CHO cells in vitro.

Authors:  E Bocian; M Laverick; A H Nias
Journal:  Br J Cancer       Date:  1983-12       Impact factor: 7.640
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.