Effect of a 2 week course of oral salbutamol on adrenomedullary function in normal subjects.

1 The adrenal medullary response to intravenous histamine infusions (0.1 and 0.4 micrograms kg-1 min-1 histamine base) was studied in six normal subjects. 2 After a 2 week course of oral salbutamol (8 mg slow release twice daily) plasma adrenaline levels, thought to reflect adrenomedullary function, were unchanged both at rest and in response to histamine infusion. 3 The present study does not support our original hypothesis that salbutamol may be capable of suppressing the adrenal medulla in normal subjects.