Stage IB cervical carcinoma and pregnancy: report of 49 cases.

In a study of 49 cases of Stage IB cervical carcinoma associated with pregnancy, the 5-year survival rate was 69.8%, the incidence of tumor-positive pelvic lymph nodes was 25.0%, and the posttreatment serious complication rate was 22.4%. These were significantly different from parameters generated in our center's overall experience with Stage IB cervical carcinoma (p less than 0.001, p less than 0.05, and p less than 0.001). When associated with pregnancy, the 28.8% serious complication rate in patients receiving radiotherapy was significantly higher (p less than 0.025) than the 6.7% rate observed in patients undergoing radical hysterectomy and lymph node dissection. No effect on 5-year survival was observed regarding time of gestation when diagnosis was made, method of delivery, or treatment modality. A subgroup of patients with diagnosis made in the second or third trimester all underwent cesarean section and appeared to have improved survival when radical hysterectomy and lymph node dissection accompanied this procedure as compared to those patients having postpartum radiotherapy.