Literature DB >> 6847384

Investigation of the mechanism of cadmium toxicity at cellular level. I. A light microscopical study.

A F Morselt, J H Peereboom-Stegeman, E J Jongstra-Spaapen, J James.   

Abstract

Chromatin condensation occurs within 15 min to 1 h after the addition of CdCl2 in a concentration of 1 microgram/ml to a liver cell culture and seems to be the first event demonstrable by light microscopy. This chromatin condensation, which precedes membrane leakage, is irreversible and leads to cell death of almost all cells. It does not occur after the administration of equimolecular concentrations of some other bivalent metallic ions.

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Year:  1983        PMID： 6847384     DOI： 10.1007/bf00354769

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  9 in total

1.  Microphotometry of rat liver nucleoproteins. I. Differences in Naphtol Yellow S total nucleoprotein and Fastgreen histon content between parenchymal and littoral cell nuclei.

Authors:  A F Morselt; V Maarschalkerweerd
Journal:  Histochemistry       Date:  1974

2.  The naphthol yellow S stain for proteins tested in a model system of polyacrylamide films and evaluated for practical use in histochemistry.

Authors:  J Tas; P Oud; J James
Journal:  Histochemistry       Date:  1974

3.  Relationship between the fine structural organization of chromatin and nucleic acid synthesis in regenerating rat hepatocytes.

Authors:  M Derenzini; A Pession-Brizzi; C Betts-Eusebi; F Novello
Journal:  J Ultrastruct Res       Date:  1981-05

4.  Cadmium modification of nucleolar ultrastructure and RNA synthesis in Physarum polycephalum.

Authors:  J F Sina; B Chin
Journal:  Toxicol Appl Pharmacol       Date:  1978-03       Impact factor: 4.219

5.  Relationship between chromatin and perichromatin granules in cadmium-treated isolated hepatocytes.

Authors:  F Puvion-Dutilleul; E Puvion
Journal:  J Ultrastruct Res       Date:  1981-03

6.  Application of the Barr and Stround GN5 densitometer for description of the chromatin structure.

Authors:  W M Frederiks; A Slob; M Schröder
Journal:  Microsc Acta       Date:  1980-09

7.  Functional significance of perichromatin granule accumulation induced by cadmium chloride in isolated rat liver cells.

Authors:  E Puvion; M Lange
Journal:  Exp Cell Res       Date:  1980-07       Impact factor: 3.905

8.  The role of metallothionein synthesis in cadmium- and zinc-resistant CHO-K1M cells.

Authors:  G Gick; K S McCarty; K S McCarty
Journal:  Exp Cell Res       Date:  1981-03       Impact factor: 3.905

9.  The effect of a single sublethal administration of cadmium chloride on the microcirculation in the uterus of the rat.

Authors:  J H Peereboom-Stegeman; E J Jongstra-Spaapen
Journal:  Toxicology       Date:  1979-08       Impact factor: 4.221
  9 in total
  7 in total

1.  Combined effect of cadmium (CdCl2) and high temperature on HeLa S3 cells.

Authors:  T Kishimoto; Y Fukuzawa; M Tada
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

2.  Chromatin condensation in the erythrocytes of fish following exposure to cadmium.

Authors:  T S Gill; J C Pant
Journal:  Bull Environ Contam Toxicol       Date:  1986-02       Impact factor: 2.151

3.  Effect of cadmium chloride on cell division and chromosomes in Chinese hamster ovary cells.

Authors:  B C Lakkad; S K Nigam; A B Karnik; K N Thakore; B B Chatterjee
Journal:  Bull Environ Contam Toxicol       Date:  1986-03       Impact factor: 2.151

4.  Large increase in disulphide bonds containing cytosol proteins after chronic cadmium administration, estimated in isolated rat liver cells.

Authors:  A F Morselt; C J van de Hamer; L Prinsen; E J Jongstra-Spaapen; J H Copius Peereboom-Stegeman; K S Bosch
Journal:  Histochemistry       Date:  1985

5.  Effect of cadmium (CdCl2) on cell proliferation and production of EDRF (endothelium-derived relaxing factor) by cultured human umbilical arterial endothelial cells.

Authors:  T Kishimoto; T Oguri; M Ohno; K Matsubara; K Yamamoto; M Tada
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

6.  Cadmium-induced hepatotoxicity in cultured rat hepatocytes as evaluated by morphometric analysis.

Authors:  E M Sorensen; D Acosta
Journal:  In Vitro       Date:  1984-10

7.  Transformation of prostatic epithelial cells and fibroblasts with cadmium chloride in vitro.

Authors:  L Terracio; M Nachtigal
Journal:  Arch Toxicol       Date:  1986-02       Impact factor: 5.153
  7 in total

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