A technique for laser Raman spectroscopic studies of isolated cell populations.

A new method has been developed for the study of cell populations by laser Raman spectroscopy. Resonance Raman spectra of a small number of living or fixed tumor cells (ca 5000) treated with the antitumor agent adriamycin have been successfully obtained. This new approach leads to a better understanding of the molecular interactions between drug and biological targets, i.e., nuclear DNA at the cellular level.