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Literature DB >> 6844357

Dominant susceptibility effect on the murine corneal response to Pseudomonas aeruginosa.

Abstract

Natural host resistance to Pseudomonas aeruginosa corneal infection is regulated by two complementing dominant genes PsCR1 and PsCR2 (RS Berk, MA Leon, LD Hazlett. Infect Immun 26:1221-1223, 1979). In this study we have demonstrated a third dominant gene, which determines susceptibility to P. aeruginosa-induced eye damage. This gene was designated as PsCS. The F1 progeny from matings between the resistant DBA/2J strain and the susceptible strain C57BL/6J and C3H/HeJ displayed the susceptibility phenotype. Backcross and F2 studies using the C3H/HeJ and DBA/2J strains suggested the presence of two linked PsCS loci.

Entities: Disease Gene Species

Mesh：

Year: 1983 PMID： 6844357 DOI： 10.3181/00379727-172-41592

Source DB: PubMed Journal: Proc Soc Exp Biol Med ISSN： 0037-9727

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Cited

17 in total

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Authors: N Duran; A Koc; H Oksuz; C Tamer; Y Akaydin; T Kozlu; M Celik
Journal: Mol Cell Biochem Date: 2006-01 Impact factor: 3.396

2. Type III secretion-dependent modulation of innate immunity as one of multiple factors regulated by Pseudomonas aeruginosa RetS.

Authors: Irandokht Zolfaghar; David J Evans; Reza Ronaghi; Suzanne M J Fleiszig
Journal: Infect Immun Date: 2006-07 Impact factor: 3.441

3. Factors impacting corneal epithelial barrier function against Pseudomonas aeruginosa traversal.

Authors: Irania Alarcon; Connie Tam; James J Mun; Jeffrey LeDue; David J Evans; Suzanne M J Fleiszig
Journal: Invest Ophthalmol Vis Sci Date: 2011-03-14 Impact factor: 4.799

4. Proinflammatory cytokine deficiency and pathogenesis of Pseudomonas aeruginosa keratitis in aged mice.

Authors: J A Hobden; S A Masinick; R P Barrett; L D Hazlett
Journal: Infect Immun Date: 1997-07 Impact factor: 3.441

5. Development of a Broad-Spectrum Antimicrobial Combination for the Treatment of Staphylococcus aureus and Pseudomonas aeruginosa Corneal Infections.

Authors: Michaelle Chojnacki; Alesa Philbrick; Benjamin Wucher; Jordan N Reed; Andrew Tomaras; Paul M Dunman; Rachel A F Wozniak
Journal: Antimicrob Agents Chemother Date: 2018-12-21 Impact factor: 5.191

Dominant susceptibility effect on the murine corneal response to Pseudomonas aeruginosa.

1. The protective role of topical propolis on experimental keratitis via nitric oxide levels in rabbits.

2. Type III secretion-dependent modulation of innate immunity as one of multiple factors regulated by Pseudomonas aeruginosa RetS.

3. Factors impacting corneal epithelial barrier function against Pseudomonas aeruginosa traversal.

4. Proinflammatory cytokine deficiency and pathogenesis of Pseudomonas aeruginosa keratitis in aged mice.

5. Development of a Broad-Spectrum Antimicrobial Combination for the Treatment of Staphylococcus aureus and Pseudomonas aeruginosa Corneal Infections.

6. Effect of C3 depletion on experimental Pseudomonas aeruginosa ocular infection: histopathological analysis.

7. Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections.

8. Rapid and sensitive method for evaluating Pseudomonas aeruginosa virulence factors during corneal infections in mice.

9. Twitching motility contributes to the role of pili in corneal infection caused by Pseudomonas aeruginosa.

10. Serum antibody response to Pseudomonas aeruginosa antigens during corneal infection.