| Literature DB >> 684426 |
A Kales, M B Scharf, J D Kales.
Abstract
Rebound insomnia followed the withdrawal of three benzodiazepine hypnotic drugs, each of which had been administered in a single nightly dose for only short-term periods. The intense worsening of sleep is attributed to the short duration of the action of these drugs. A hypothesis involving benzodiazepine receptors in the brain is proposed in which there is a delay or lag in replacement of endogenous benzodiazepine-like molecules after the abrupt withdrawal of exogenous drugs.Entities:
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Year: 1978 PMID： 684426 DOI： 10.1126/science.684426
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728