Literature DB >> 6843551

An inhibitor of polyamine synthesis arrests cells at an earlier stage of G1 than does calcium deprivation.

B F Cheetham.   

Abstract

Methylglyoxal bis(guanylhydrazone) completely inhibits the induction of thymidine kinase after serum stimulation of quiescent fibroblasts only if added within 3 h after serum, whereas calcium deprivation blocks this induction up to 12 h after serum stimulation. Experiments in which one of these blocks was imposed as the other was released confirmed that cells blocked by methylglyoxal bis(guanylhydrazone) are arrested at an earlier stage in G1 than cells blocked by calcium deprivation.

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Year:  1983        PMID： 6843551      PMCID： PMC368558          DOI： 10.1128/mcb.3.3.480-483.1983

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  7 in total

1.  The use of conditional lethal cell cycle mutants for temporal and functional sequence mapping of cell cycle events.

Authors:  J R Pringle
Journal:  J Cell Physiol       Date:  1978-06       Impact factor: 6.384

2.  Methyl glyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases.

Authors:  H G Williams-Ashman; A Schenone
Journal:  Biochem Biophys Res Commun       Date:  1972-01-14       Impact factor: 3.575

3.  A restriction point for control of normal animal cell proliferation.

Authors:  A B Pardee
Journal:  Proc Natl Acad Sci U S A       Date:  1974-04       Impact factor: 11.205

4.  Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants.

Authors:  L H Hartwell; R K Mortimer; J Culotti; M Culotti
Journal:  Genetics       Date:  1973-06       Impact factor: 4.562

5.  A biochemical investigation of the adenovirus-induced G1 to S phase progression: thymidine kinase, ornithine decarboxylase, and inhibitors of polyamine biosynthesis.

Authors:  B F Cheetham; A J Bellett
Journal:  J Cell Physiol       Date:  1982-02       Impact factor: 6.384

6.  Related effects of calcium and serum on the G1 phase of the human W138 fibroblast.

Authors:  J T Tupper; L Kaufman; P V Bodine
Journal:  J Cell Physiol       Date:  1980-07       Impact factor: 6.384

7.  Potential inhibitors of polyamine biosynthesis. 2. alpha-Alkyl- and benzyl-(+/-)-ornithine.

Authors:  M M Abdel-Monem; N E Newton; B C Ho; C E Weeks
Journal:  J Med Chem       Date:  1975-06       Impact factor: 7.446
  7 in total
  1 in total

1.  Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression.

Authors:  Wei He; Eunmiri Roh; Ke Yao; Kangdong Liu; Xing Meng; Fangfang Liu; Penglei Wang; Ann M Bode; Zigang Dong
Journal:  NPJ Precis Oncol       Date:  2017-04-27
  1 in total

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