Literature DB >> 684279

Amobarbital metabolism in man: N-glucoside formation.

B K Tang, W Kalow, A A Grey.   

Abstract

N-Hydroxyamobarbital, the compound previously proposed as the second major metabolite of amobarbital was synthesized. The metabolite was shown not to be N-hydroxyamobarbital. NMR and MS analyses on the metabolite suggested it could be a derivative of N-beta-D-glucopyranoside. This proposed structure was confirmed by comparison with the spectral data of synthetic amobarbital-N-methyl-N-2,3,4,6-tetraacetyl-beta-D-glucopyranoside.

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Year:  1978        PMID: 684279

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN: 0034-5164


  7 in total

1.  Stereochemical characterization of the diastereomers of the amobarbital N-glucosides excreted in human urine.

Authors:  W H Soine; P J Soine; F C Wireko; D J Abraham
Journal:  Pharm Res       Date:  1990-08       Impact factor: 4.200

Review 2.  Ethnic differences in drug metabolism.

Authors:  W Kalow
Journal:  Clin Pharmacokinet       Date:  1982 Sep-Oct       Impact factor: 6.447

3.  Disposition of hexobarbitone in healthy man: kinetics of parent drug and metabolites following oral administration.

Authors:  N P Vermeulen; C T Rietveld; D D Breimer
Journal:  Br J Clin Pharmacol       Date:  1983-04       Impact factor: 4.335

4.  Identification of the diastereomers of pentobarbital N-glucosides excreted in human urine.

Authors:  W H Soine; P J Soine; T M England; R M Graham; G Capps
Journal:  Pharm Res       Date:  1994-11       Impact factor: 4.200

5.  Stereochemical characterization of the diastereomers of the phenobarbital N-beta-D-glucose conjugate excreted in human urine.

Authors:  W H Soine; P J Soine; S E Mongrain; T M England
Journal:  Pharm Res       Date:  1990-04       Impact factor: 4.200

6.  A novel metabolic pathway of morphine: formation of morphine glucosides in cancer patients.

Authors:  X Y Chen; L M Zhao; D F Zhong
Journal:  Br J Clin Pharmacol       Date:  2003-06       Impact factor: 4.335

7.  Stability of phenobarbital N-glucosides: identification of hydrolysis products and kinetics of decomposition.

Authors:  F B Vest; W H Soine; R B Westkaemper; P J Soine
Journal:  Pharm Res       Date:  1989-06       Impact factor: 4.200

  7 in total

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