| Literature DB >> 6842190 |
Y Sanchez, I Ionescu-Matiu, J L Melnick, G R Dreesman.
Abstract
Three hepatitis B surface antigen (HBsAg) preparations were compared: purified intact 22-nm HBsAg particles; HBsAg-derived, sodium dodecyl sulfate (SDS)-denatured P25 + GP30 polypeptide pool; and nondenatured P25 + GP30 micelles. The micelles had the same polypeptide composition as the P25 + GP30 pool. The immunogenicity in mice of each preparation, administered either in saline suspension or adsorbed to aluminum gel, was compared. The SDS-denatured polypeptides were less immunogenic than intact HBsAg particles, whereas the micelles were more immunogenic. High anti-HBs titers were observed in mice immunized with micelle preparations in either saline suspension or adsorbed to aluminum gel for as long as 200 days after a booster inoculation, administered 26 days after the primary dose.Entities:
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Year: 1983 PMID： 6842190 DOI： 10.1002/jmv.1890110205
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 2.327