Literature DB >> 6841966

Genetic study of norepinephrine in brains of mice selected for differences in blood pressure.

G Schlager, R Freeman, A A El Seoudy.   

Abstract

Norepinephrine concentration of the whole brain was found to be statistically different between the HBP and LBP mouse stains that had been selectively bred for high and low systolic blood pressure, respectively. Crosses between these strains resulted in statistically different NE levels between the reciprocal F1 males and the genetical analysis revealed a significant sex-linked factor or factors. Dissection of the brain into eight regions and subsequent biochemical analyses revealed statistically higher NE content in the LBP compared to the HBP for midbrain and cerebellum. Midbrain NE was also significantly different between the reciprocal F1's. NE concentration was then related to known behavioral characteristics in these strains.

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Year:  1983        PMID: 6841966     DOI: 10.1093/oxfordjournals.jhered.a109749

Source DB:  PubMed          Journal:  J Hered        ISSN: 0022-1503            Impact factor:   2.645


  5 in total

1.  Norepinephrine level in the hypothalamus of the genetically hypertensive mouse.

Authors:  G Schlager; R Freeman
Journal:  Experientia       Date:  1983-07-15

2.  The effect of nicotine on blood pressure in the genetically hypertensive mouse.

Authors:  L C Backer; G Schlager
Journal:  Experientia       Date:  1984-12-15

Review 3.  Mechanisms Responsible for Genetic Hypertension in Schlager BPH/2 Mice.

Authors:  Kristy L Jackson; Geoffrey A Head; Cindy Gueguen; Emily R Stevenson; Kyungjoon Lim; Francine Z Marques
Journal:  Front Physiol       Date:  2019-10-18       Impact factor: 4.566

4.  Renal Denervation and Celiac Ganglionectomy Decrease Mean Arterial Pressure Similarly in Genetically Hypertensive Schlager (BPH/2J) Mice.

Authors:  Ninitha Asirvatham-Jeyaraj; Madeline M Gauthier; Christopher T Banek; Abhismitha Ramesh; Hannah Garver; Gregory D Fink; John W Osborn
Journal:  Hypertension       Date:  2021-01-04       Impact factor: 10.190

5.  Circadian Differences in the Contribution of the Brain Renin-Angiotensin System in Genetically Hypertensive Mice.

Authors:  Kristy L Jackson; Francine Z Marques; Kyungjoon Lim; Pamela J Davern; Geoffrey A Head
Journal:  Front Physiol       Date:  2018-03-19       Impact factor: 4.566

  5 in total

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