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Literature DB >> 6841643

Raised 5-hydroxytryptamine concentrations in enterochromaffin cells in adult coeliac disease.

Abstract

We measured cytofluorometrically the concentration of 5-hydroxytryptamine (5-HT, serotonin) of individual enterochromaffin (EC) cells in adult coeliac and non-coeliac small intestinal mucosa. The distributions of 5-HT concentration within populations of EC cells in control and coeliac mucosae were log normal and thus contained one single population of EC cells. The median 5-HT concentration per EC cell, and the number of EC cells both increased in coeliac disease, but showed signs of normalisation when gluten was withdrawn from the diet. The results indicate that, besides inducing EC cell hyperplasia, gluten is capable of producing reversible changes in functions of EC cells in adult coeliac disease.

Entities: Chemical Disease

Mesh：

Substances：
Serotonin
Glutens

Year: 1983 PMID： 6841643 PMCID： PMC498273 DOI： 10.1136/jcp.36.5.499

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

18 in total

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Authors: B D PIMPARKAR; D SENESKY; M H KALSER
Journal: Gastroenterology Date: 1961-04 Impact factor: 22.682

2. Vagal influence on serotonin concentration in enterochromaffin cells in the cat.

Authors: H Ahlman; A Dahlström; J Kewenter; J Lundberg
Journal: Acta Physiol Scand Date: 1976-07

3. Increased excretion of 5-hydroxyindoleacetic acid in urine of children with untreated coeliac disease.

Authors: D N Challacombe; G A Brown; S C Black; M H Storrie
Journal: Arch Dis Child Date: 1972-06 Impact factor: 3.791

4. Mast cells in carcinoid tumours. Distribution, histochemical properties and 5-hydroxytryptamine content.

Authors: L Enerbäck
Journal: Acta Pathol Microbiol Scand Date: 1965

5. Effect of vagal stimulation on duodenal serotonin in the guinea pig.

Authors: F J Hohenleitner; M F Tansy; R H Golder
Journal: J Pharm Sci Date: 1971-03 Impact factor: 3.534

6. The influence of serotonin on crypt cell proliferation in the jejunum of rat.

Authors: P J Tutton
Journal: Virchows Arch B Cell Pathol Date: 1974

7. Validation and application of a radioimmunoassay for serotonin.

Authors: J M Kellum; B M Jaffe
Journal: Gastroenterology Date: 1976-04 Impact factor: 22.682

8. A cytofluorometric and radiochemical analysis of the uptake and turnover of 5-hydroxytryptamine in mast cells.

Authors: L Enerbäck; J Jarlstedt
Journal: J Histochem Cytochem Date: 1975-02 Impact factor: 2.479

9. The cell cycle time in the flat (avillous) mucosa of the human small intestine.

Authors: N Wright; A Watson; A Morley; D Appleton; J Marks; A Douglas
Journal: Gut Date: 1973-08 Impact factor: 23.059

10. Cytofluorometric quantitation of 5-hydroxytryptamine in mast cells: an improved technique for the formaldehyde condensation reaction.

Authors: L Enerbäck; B Gustafsson; L Mellblom
Journal: J Histochem Cytochem Date: 1977-01 Impact factor: 2.479

6 in total

1. 5-HT containing enteroendocrine cells characterised by morphologies, patterns of hormone co-expression, and relationships with nerve fibres in the mouse gastrointestinal tract.

Authors: Ada Koo; Linda J Fothergill; Hirofumi Kuramoto; John B Furness
Journal: Histochem Cell Biol Date: 2021-02-19 Impact factor: 4.304