Effects of 16,16-dimethyl-PGE2-methyl ester on aspirin- and indomethacin-induced gastric and intestinal lesions in mini pigs.

Aspirin, 100 mg/kg, given only twice at intervals of 16 h to fasted mini pigs induced lesions in the body but had no effect on the antrum and small intestine. Indomethacin, 40 mg/kg, given once daily for 10 consecutive days to non-fasted mini pigs very weakly irritated the pig stomach but induced multiple superficial lesions in the jejunum and ileum. 16,16-Dimethyl-PGE2-methyl ester, 10 micrograms/kg in two divided doses or 20 micrograms/kg in four divided doses for 10 days, markedly inhibited the aspirin- or indomethacin-induced gastric and intestinal lesions in mini pigs, respectively.