Literature DB >> 6840189

Anticonvulsant activity of some 2-aminoethanesulphonic acid (taurine) derivatives.

S S Oja, P Kontro, I B Lindén, G Gothóni.   

Abstract

A number of aliphatic 2-aminoethanesulphonic acid (taurine) derivatives were tested for their anticonvulsant activity in maximal electroshock seizure and pentylenetetrazole seizure threshold tests in mice. Certain piperidino, benzamido, phthalimido and phenylsuccinylimido derivatives were effective. Phthalimidoethanesulphon-N-methylamide, which inhibited the binding of both taurine and GABA to isolated synaptic membranes, appeared the best anticonvulsant among the derivatives tested.

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Year:  1983        PMID： 6840189     DOI： 10.1016/0014-2999(83)90329-1

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Taurine as osmoregulator and neuromodulator in the brain.

Authors:  S S Oja; P Saransaari
Journal:  Metab Brain Dis       Date:  1996-06       Impact factor: 3.584

2.  Modification of chloride flux across brain membranes by inhibitory amino acids in developing and adult mice.

Authors:  S S Oja; E R Korpi; P Saransaari
Journal:  Neurochem Res       Date:  1990-08       Impact factor: 3.996

3.  Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice.

Authors:  Nina Isoherranen; Boris Yagen; Ofer Spiegelstein; Richard H Finnell; Michelle Merriweather; Jose H Woodhead; Bogdan Wlodarczyk; H Steve White; Meir Bialer
Journal:  Br J Pharmacol       Date:  2003-06       Impact factor: 8.739

Review 4.  Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms.

Authors:  Md Jakaria; Shofiul Azam; Md Ezazul Haque; Song-Hee Jo; Md Sahab Uddin; In-Su Kim; Dong-Kug Choi
Journal:  Redox Biol       Date:  2019-05-21       Impact factor: 11.799

5.  Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4- and N-substituted benzoyltaurinamide derivatives.

Authors:  Özlem AkgÜl; Mümin Alper ErdoĞan; Derviş Bİrİm; Çağla KayabaŞi; Cumhur GÜndÜz; Güliz ArmaĞan
Journal:  Turk J Chem       Date:  2020-12-16       Impact factor: 1.239

6.  Advances in drug design based on the amino Acid approach: taurine analogues for the treatment of CNS diseases.

Authors:  Man Chin Chung; Pedro Malatesta; Priscila Longhin Bosquesi; Paulo Renato Yamasaki; Jean Leandro Dos Santos; Ednir Oliveira Vizioli
Journal:  Pharmaceuticals (Basel)       Date:  2012-10-23
  6 in total

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