Literature DB >> 6840126

Potential radiopharmaceuticals for the detection of ocular melanoma. Part I. 5-iodo-2-thiouracil derivatives.

A van Langevelde, C N Bakker, H J Broxterman, J G Journée-de Korver, F M Kaspersen, J A Oosterhuis, E K Pauwels.   

Abstract

The tissue distribution of a number of 5-[131I]-iodo-2-thiouracil derivatives was measured in Syrian golden hamsters with Greene melanoma. These compounds were rapidly (in less than 1 h) distributed in all tissues, while in most tissues fast elimination (T1/2 1-3 h) was observed. Because of retention of the 131I activity in the tumour, high tumour/non-tumour tissue ratios were found (e.g. tumour/eye 2.3-10, tumour/skin 1.5-3) suggesting that some of these compounds might be used as melanoma delineating agents, when labelled with 123I.

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Year:  1983        PMID： 6840126     DOI： 10.1007/bf00252555

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  9 in total

1.  Radionuclidic explorations in ophthalmology.

Authors:  N Safi; P Blanquet; B Basse-Cathalina; D Ducassou; P Verin
Journal:  Int J Nucl Med Biol       Date:  1975-10

2.  S-DEMETHYLATION BY MICROSOMAL ENZYMES.

Authors:  P MAZEL; J F HENDERSON; J AXELROD
Journal:  J Pharmacol Exp Ther       Date:  1964-01       Impact factor: 4.030

3.  Biosynthesis of a thouracil pheomelanin in embryonic pigment cells exposed to thouracil.

Authors:  J R Whittaker
Journal:  J Biol Chem       Date:  1971-10-25       Impact factor: 5.157

4.  Metabolism of 35S-labelled antithyroid drugs in man.

Authors:  W D Alexander; V Evans; A MacAulay; T F Gallagher; J Londono
Journal:  Br Med J       Date:  1969-05-03

5.  125I-labelled chloroquine analog in the diagnosis of ocular melanomas.

Authors:  C M Boyd; W H Beierwaltes; L M Lieberman; T J Bergstrom
Journal:  J Nucl Med       Date:  1971-09       Impact factor: 10.057

6.  Melanin binding properties of iodoquine.

Authors:  M S Blois
Journal:  J Invest Dermatol       Date:  1968-03       Impact factor: 8.551

7.  Metal isotopes used as radioactive indicators of ocular melanoma.

Authors:  S Packer; R M Lambrecht; D R Christman; A N Ansari; A P Wolf; H L Atkins
Journal:  Am J Ophthalmol       Date:  1977-01       Impact factor: 5.258

8.  Melanoma affine radiopharmaceuticals I. A comparative study of 131I-labeled quinoline and tyrosine derivatives.

Authors:  B Bubeck; M Eisenhut; U Heimke; K zum Winkel
Journal:  Eur J Nucl Med       Date:  1981

9.  False precursors of melanin as selective melanoma seekers.

Authors:  L Dencker; B Larsson; K Olander; S Ullberg; M Yokota
Journal:  Br J Cancer       Date:  1979-04       Impact factor: 7.640
  9 in total
  4 in total

1.  A patient study with radioiodine labelled 5-iodo-2-thiouracil.

Authors:  A van Langevelde; W Bergman; R I Feitsma; S Osanto; E K Pauwels
Journal:  Eur J Nucl Med       Date:  1988

2.  Potential radiopharmaceuticals for the detection of ocular melanoma. Part II. Iodoquinoline derivatives and 67Ga-citrate.

Authors:  A van Langevelde; C N Bakker; H Boer; T A Ilmer; J A Journée-de Korver; F M Kaspersen; E L Noach; J A Oosterhuis; E K Pauwels
Journal:  Eur J Nucl Med       Date:  1986

3.  Localization of 11C-radiopharmaceuticals in the Greene melanoma of hamsters.

Authors:  J H Turner; M Maziere; D Comar
Journal:  Eur J Nucl Med       Date:  1985

4.  Potential radiopharmaceuticals for the detection of ocular melanoma. Part III. A study with 14C and 11C labelled tyrosine and dihydroxyphenylalanine.

Authors:  A van Langevelde; H D van der Molen; J G Journée-de Korver; A M Paans; E K Pauwels; W Vaalburg
Journal:  Eur J Nucl Med       Date:  1988
  4 in total

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