Literature DB >> 6840062

Levels of metallothionein messenger RNA in foetal, neonatal and maternal rat liver.

R D Andersen, J E Piletz, B W Birren, H R Herschman.   

Abstract

We have used translation in vitro of hepatic polyadenylated RNA to characterize the levels of metallothionein mRNA in foetal, neonatal, pregnant and nulliparous rats. The translation products of foetal hepatic metallothionein mRNA increased relative to other mRNA translation products from day 18 of gestation to birth and attained a maximum, maintained throughout suckling, which is tenfold above 17-day foetal hepatic levels and fourfold above adult levels. Maternal liver metallothionein mRNA decreased fivefold between 17 days and 20 days of gestation, rose sharply immediately before birth, and was low throughout lactation.

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Year:  1983        PMID： 6840062     DOI： 10.1111/j.1432-1033.1983.tb07289.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  11 in total

1.  Cadmium-induced differential accumulation of metallothionein isoforms in the Antarctic icefish, which exhibits no basal metallothionein protein but high endogenous mRNA levels.

Authors:  V Carginale; R Scudiero; C Capasso; A Capasso; P Kille; G di Prisco; E Parisi
Journal:  Biochem J       Date:  1998-06-01       Impact factor: 3.857

2.  Comparative study on metallothionein induction in whole testicular tissue and isolated Leydig cells.

Authors:  J Abel; N de Ruiter; W N Kühn-Velten
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

3.  Molecular cloning of chicken metallothionein. Deduction of the complete amino acid sequence and analysis of expression using cloned cDNA.

Authors:  D Y Wei; G K Andrews
Journal:  Nucleic Acids Res       Date:  1988-01-25       Impact factor: 16.971

4.  Evidence for differences in the post-transcriptional regulation of rat metallothionein isoforms.

Authors:  M H Vasconcelos; S C Tam; J H Beattie; J E Hesketh
Journal:  Biochem J       Date:  1996-04-15       Impact factor: 3.857

5.  Rat metallothionein-1 structural gene and three pseudogenes, one of which contains 5'-regulatory sequences.

Authors:  R D Andersen; B W Birren; S J Taplitz; H R Herschman
Journal:  Mol Cell Biol       Date:  1986-01       Impact factor: 4.272

6.  Difference in hepatic metallothionein content in Antarctic red-blooded and haemoglobinless fish: undetectable metallothionein levels in haemoglobinless fish is accompanied by accumulation of untranslated metallothionein mRNA.

Authors:  R Scudiero; V Carginale; M Riggio; C Capasso; A Capasso; P Kille; G di Prisco; E Parisi
Journal:  Biochem J       Date:  1997-02-15       Impact factor: 3.857

7.  Variations in hepatic metallothionen, zinc and copper levels during an annual reproductive cycle in rainbow trout,Salmo gairdneri.

Authors:  P E Olsson; C Haux; L Förlin
Journal:  Fish Physiol Biochem       Date:  1987-01       Impact factor: 2.794

8.  Cell specificity and an effect of ras on human metallothionein gene expression.

Authors:  C J Schmidt; D H Hamer
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

9.  Isolation of mouse isometallothioneins. A comparison of isometallothioneins in growing cells and post-mitotic cells.

Authors:  S Kobayashi; J Sayato-Suzuki
Journal:  Biochem J       Date:  1988-05-01       Impact factor: 3.857

10.  Variation in the amounts of hepatic copper, zinc and metallothionein mRNA during development in the rat.

Authors:  J F Mercer; A Grimes
Journal:  Biochem J       Date:  1986-08-15       Impact factor: 3.857
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