Literature DB >> 6838634

Mitochondrial membrane modifications induced by adriamycin-mediated electron transport.

E Goormaghtigh, G Pollakis, J M Ruysschaert.   

Abstract

Adriamycin (ADM) was found to have a two-step mode of action on the cardiac mitochondrial membrane. (1) An interaction with cardiolipin (CL) resulted in the formation of an ADM-CL complex able to transfer electrons from NADH to cytochrome c (cyt.c) as well as coenzyme Q (CoQ). This complex formation stimulates an increased activity of NADH-CoQ oxidoreductase (complex I) and CoQ-cyt.c oxidoreductase (complex III). (2) Transfer of electrons through ADM resulted in the formation of a very strong complex between ADM and CL. This new complex is different and much stronger than the already known ADM-CL complex.

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Year:  1983        PMID： 6838634     DOI： 10.1016/0006-2952(83)90593-2

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  12 in total

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3.  Cellular pharmacology and antitumor activity of N-(p-azidobenzoyl)-daunorubicin, a photoactive anthracycline analogue.

Authors:  S D Averbuch; R E Clawson; N R Bachur; R L Felsted
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4.  Is the drug-responsive NADH oxidase of the cancer cell plasma membrane a molecular target for adriamycin?

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5.  Oxidative and non-oxidative mechanisms in the inactivation of cardiac mitochondrial electron transport chain components by doxorubicin.

Authors:  O Marcillat; Y Zhang; K J Davies
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Review 6.  Clinical pharmacokinetics of doxorubicin.

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8.  Survival of rat mammary tumor cell clones and DNA strand damage following adriamycin treatment.

Authors:  D P Evans; R E Meyn; S P Tomasovic
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

9.  Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes.

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10.  The effect of cytosine arabinoside upon mitochondrial staining kinetics in human hematopoietic cells.

Authors:  C Haanen; P Muus; A Pennings
Journal:  Histochemistry       Date:  1986
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