Literature DB >> 6838598

Size and shape of poly(ADP-ribose): examination by gel filtration, gel electrophoresis and electron microscopy.

K Hayashi, M Tanaka, T Shimada, M Miwa, T Sugimura.   

Abstract

Digestion of the poly(ADP-ribose) with snake venom phosphodiesterase yielded phosphoribosyl-AMP and AMP in a ratio of 30 to 1, indicating the "chain length" of 30 if the poly(ADP-ribose) is a linear molecule as previously supposed. Gel filtration and gel electrophoresis, however, revealed a very heterogeneous size distribution, the average size being, much longer than (ADP-ribose)30. Electron microscopy of poly(ADP-ribose) showed an irregularly branched figure. Molecules with more than ten branched portions were observed. These results are in agreement with the recent identification of the chemical structure of the branched portion in poly(ADP-ribose).

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Year:  1983        PMID： 6838598     DOI： 10.1016/0006-291x(83)91803-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  14 in total

Review 1.  Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.

Authors:  D D'Amours; S Desnoyers; I D'Silva; G G Poirier
Journal:  Biochem J       Date:  1999-09-01       Impact factor: 3.857

2.  The role of transforming growth factor-beta in suppression of hepatic metastasis from colon cancer.

Authors:  Chandrakanth Are; Neka Simms; Ashwani Rajput; Ashwani Rajupt; Michael Brattain
Journal:  HPB (Oxford)       Date:  2010-09       Impact factor: 3.647

Review 3.  Molecular and biochemical features of poly (ADP-ribose) metabolism.

Authors:  D Lautier; J Lagueux; J Thibodeau; L Ménard; G G Poirier
Journal:  Mol Cell Biochem       Date:  1993-05-26       Impact factor: 3.396

Review 4.  Joining the PARty: PARP Regulation of KDM5A during DNA Repair (and Transcription?).

Authors:  Anthony Sanchez; Bethany A Buck-Koehntop; Kyle M Miller
Journal:  Bioessays       Date:  2022-05-09       Impact factor: 4.653

5.  The C-Terminal Domain of Y-Box Binding Protein 1 Exhibits Structure-Specific Binding to Poly(ADP-Ribose), Which Regulates PARP1 Activity.

Authors:  Konstantin N Naumenko; Mariya V Sukhanova; Loic Hamon; Tatyana A Kurgina; Rashid O Anarbaev; Aswin Mangerich; David Pastré; Olga I Lavrik
Journal:  Front Cell Dev Biol       Date:  2022-06-21

6.  Large-scale preparation and characterization of poly(ADP-ribose) and defined length polymers.

Authors:  Edwin S Tan; Kristin A Krukenberg; Timothy J Mitchison
Journal:  Anal Biochem       Date:  2012-06-26       Impact factor: 3.365

7.  Poly(ADP-ribose): historical perspective.

Authors:  T Sugimura; M Miwa
Journal:  Mol Cell Biochem       Date:  1994-09       Impact factor: 3.396

Review 8.  Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.

Authors:  Carles Cantó; Anthony A Sauve; Peter Bai
Journal:  Mol Aspects Med       Date:  2013-01-25

9.  Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells.

Authors:  Neka A K Simms; Ashwani Rajput; Elizabeth A Sharratt; Melanie Ongchin; Carol A Teggart; Jing Wang; Michael G Brattain
Journal:  BMC Cancer       Date:  2012-06-06       Impact factor: 4.430

Review 10.  PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling.

Authors:  Lotte van Beek; Éilís McClay; Saleha Patel; Marianne Schimpl; Laura Spagnolo; Taiana Maia de Oliveira
Journal:  Int J Mol Sci       Date:  2021-05-12       Impact factor: 5.923
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