Literature DB >> 6838557

Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite.

L Touqui, C Jacquemin, B B Vargaftig.   

Abstract

3H-PAF-acether (Alkyl-[1', 2'-3H]- 2-acetyl-sn-glyceryl-3-phosphorylcholine) was time-dependently transformed by plasma-free rabbit platelets into an unknown product, "PX", which was distinct from lyso-PAF-acether. This effect was specific for platelets since plasma only converted 3H-PAF-acether into lyso-3H-PAF-acether and platelets were not effective in metabolizing lyso-3H-PAF-acether. Platelet aggregation did not interfere with the formation of "PX". The latter is a novel platelet metabolite of PAF-acether with as yet unknown biological properties.

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Year:  1983        PMID： 6838557     DOI： 10.1016/0006-291x(83)91045-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Binding and metabolism of platelet-activating factor by human neutrophils.

Authors:  J T O'Flaherty; J R Surles; J Redman; D Jacobson; C Piantadosi; R L Wykle
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808

2.  The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets.

Authors:  L Touqui; A M Shaw; C Dumarey; C Jacquemin; B B Vargaftig
Journal:  Biochem J       Date:  1987-01-15       Impact factor: 3.857

3.  Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked.

Authors:  L Touqui; M Hatmi; B B Vargaftig
Journal:  Biochem J       Date:  1985-08-01       Impact factor: 3.857

4.  Arachidonyl transfer from diacyl phosphatidylcholine to ether phospholipids in rat platelets.

Authors:  O Colard; M Breton; G Bereziat
Journal:  Biochem J       Date:  1984-09-15       Impact factor: 3.857

5.  Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding.

Authors:  C Lartigue-Mattei; D Godeneche; J L Chabard; J Petit; J A Berger
Journal:  Agents Actions       Date:  1984-12

6.  Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets.

Authors:  E Kloprogge; J W Akkerman
Journal:  Biochem J       Date:  1984-11-01       Impact factor: 3.857

Review 7.  Platelet-activating factor in cardiovascular stress situations.

Authors:  R Rabinovici; T L Yue; G Feuerstein
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880
  7 in total

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