Amoxapine intoxication in an infant: seizures arrested with diazepam.

A 15-month-old infant had hyperpyrexia and severe generalized seizures without cardiovascular toxicity after the ingestion of 250 mg of amoxapine, a new tricyclic antidepressant of the dibenzoxapine subclass. The seizures failed to respond to physostigmine or the usual anticonvulsant therapies, but were controlled after eight hours by a second administration of diazepam. The child died 144 hours after amoxapine ingestion.