Literature DB >> 6836294

Liposomal blockade of the reticuloendothelial system: improved tumor imaging with small unilamellar vesicles.

R T Proffitt, L E Williams, C A Presant, G W Tin, J A Uliana, R C Gamble, J D Baldeschwieler.   

Abstract

The reticuloendothelial system of mice bearing EMT6 tumors was effectively blocked by intravenous injections of small unilamellar vesicles that incorporated a 6-aminomannose derivative of cholesterol in the lipid bilayer. Neutral liposomes loaded with indium-111-nitrilotriacetic acid were then injected. Fifty percent more radioactivity was deposited in tumors of the animals with blocked reticuloendothelial systems than in controls. Twenty-four hours after the injection of radioactive vesicles, well-defined tumor images were observed in whole-body gamma camera scintigraphs. Biodistribution studies showed that tumors from animals with blocked reticuloendothelial systems had more than twice the radioactivity per gram than any other tissue analyzed.

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Year:  1983        PMID： 6836294     DOI： 10.1126/science.6836294

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  24 in total

1.  Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

Authors:  D Papahadjopoulos; T M Allen; A Gabizon; E Mayhew; K Matthay; S K Huang; K D Lee; M C Woodle; D D Lasic; C Redemann
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

2.  Antigen detection in vivo after immunization with different presentation forms of rabies virus antigen, II. Cellular, but not humoral, systemic immune responses against rabies virus immune-stimulating complexes are macrophage dependent.

Authors:  I J Claassen; A D Osterhaus; M Poelen; N Van Rooijen; E Claassen
Journal:  Immunology       Date:  1998-08       Impact factor: 7.397

3.  Monitoring Tumor Response after Liposomal Doxorubicin in Combination with Liposomal Vinorelbine Treatment Using 3'-Deoxy-3'-[18F]Fluorothymidine PET.

Authors:  Chun-Yi Wu; Jo-Hsin Tang; Pei-Chia Chan; Jia-Je Li; Ming-Hsien Lin; Chih-Chieh Shen; Ren-Shyan Liu; Hsin-Ell Wang
Journal:  Mol Imaging Biol       Date:  2017-06       Impact factor: 3.488

Review 4.  The use of liposomes in the diagnosis and treatment of malignant disease.

Authors:  I Levy; J Roberts; M Baum
Journal:  Postgrad Med J       Date:  1987-10       Impact factor: 2.401

5.  Pharmacokinetics and safety of a unilamellar liposomal formulation of amphotericin B (AmBisome) in rabbits.

Authors:  J W Lee; M A Amantea; P A Francis; E E Navarro; J Bacher; P A Pizzo; T J Walsh
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

6.  Intratracheal versus intravenous liposomal delivery of siRNA, antisense oligonucleotides and anticancer drug.

Authors:  Olga B Garbuzenko; Maha Saad; Seema Betigeri; Min Zhang; Alexandre A Vetcher; Viatcheslav A Soldatenkov; David C Reimer; Vitaly P Pozharov; Tamara Minko
Journal:  Pharm Res       Date:  2008-10-29       Impact factor: 4.200

7.  Uptake of radiolabeled anti-CEA antibodies in human colorectal primary tumors as a function of tumor mass.

Authors:  L E Williams; R B Bares; J Fass; S Hauptmann; V Schumpelick; U Buell
Journal:  Eur J Nucl Med       Date:  1993-04

8.  Characterization and application of a nose-only exposure chamber for inhalation delivery of liposomal drugs and nucleic acids to mice.

Authors:  G Mainelis; S Seshadri; O B Garbuzenko; T Han; Z Wang; T Minko
Journal:  J Aerosol Med Pulm Drug Deliv       Date:  2013-03-26       Impact factor: 2.849

9.  Phosphatidylserine as a determinant of reticuloendothelial recognition of liposome models of the erythrocyte surface.

Authors:  T M Allen; P Williamson; R A Schlegel
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

10.  A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: a new strategy for heart failure diagnostics and therapeutics.

Authors:  Guillermo U Ruiz-Esparza; Victor Segura-Ibarra; Andrea M Cordero-Reyes; Keith A Youker; Rita E Serda; Ana S Cruz-Solbes; Javier Amione-Guerra; Kenji Yokoi; Dickson K Kirui; Francisca E Cara; Jesus Paez-Mayorga; Jose H Flores-Arredondo; Carlos E Guerrero-Beltrán; Gerardo Garcia-Rivas; Mauro Ferrari; Elvin Blanco; Guillermo Torre-Amione
Journal:  Eur J Heart Fail       Date:  2016-01-07       Impact factor: 15.534
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