Literature DB >> 6836278

Alcohol-induced spasms of cerebral blood vessels: relation to cerebrovascular accidents and sudden death.

B M Altura, B T Altura, A Gebrewold.   

Abstract

Ethyl alcohol produced graded contractile responses in rat cerebral arterioles and venules in vivo and in isolated canine basilar and middle cerebral arteries at a concentration range (10 to 500 milligrams per deciliter) which parallels that needed for its graded effects of euphoria, mental haziness, muscular incoordination, stupor, and coma in humans. Two specific calcium antagonists, nimodipine and verapamil, prevented or reversed the alcohol-induced cerebrovasospasm and thus may prove valuable in treating the hypertension and stroke observed in heavy users of alcohol.

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Year:  1983        PMID： 6836278     DOI： 10.1126/science.6836278

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  21 in total

Review 1.  Hypertension.

Authors:  G W Ching; D G Beevers
Journal:  Postgrad Med J       Date:  1991-03       Impact factor: 2.401

2.  Can megadoses of thiamine prevent ethanol-induced damages of rat hippocampal CA1 pyramidal neurones?

Authors:  S Wenisch; T Steinmetz; B Fortmann; R Leiser; I Bitsch
Journal:  Z Ernahrungswiss       Date:  1996-09

3.  Type 2 ryanodine receptors are highly sensitive to alcohol.

Authors:  Yanping Ye; Kuihuan Jian; Jonathan H Jaggar; Anna N Bukiya; Alex M Dopico
Journal:  FEBS Lett       Date:  2014-03-12       Impact factor: 4.124

4.  The interaction between ethanol and pregnanolone at induction of anaesthesia investigated with a threshold method in male rats.

Authors:  M D Wang; D Zhu; T Bäckström; G Wahlström
Journal:  Br J Pharmacol       Date:  2001-12       Impact factor: 8.739

5.  Moderate alcohol consumption and loss of cerebellar Purkinje cells.

Authors:  P J Karhunen; T Erkinjuntti; P Laippala
Journal:  BMJ       Date:  1994-06-25

Review 6.  'Second generation' dihydropyridine calcium antagonists. Greater vascular selectivity and some unique applications.

Authors:  D D Freedman; D D Waters
Journal:  Drugs       Date:  1987-11       Impact factor: 9.546

7.  Celastrol Dilates and Counteracts Ethanol-Induced Constriction of Cerebral Arteries.

Authors:  Kelsey North; Alexandria Slayden; Steven Mysiewicz; Anna Bukiya; Alex Dopico
Journal:  J Pharmacol Exp Ther       Date:  2020-08-29       Impact factor: 4.030

8.  Alcohol ingestion lowers supine blood pressure, causes splanchnic vasodilatation and worsens postural hypotension in primary autonomic failure.

Authors:  K R Chaudhuri; S Maule; T Thomaides; D Pavitt; C J Mathias
Journal:  J Neurol       Date:  1994-01       Impact factor: 4.849

9.  Endothelin-1 mediates the alcohol-induced reduction of pancreatic capillary blood flow.

Authors:  T Foitzik; H G Hotz; B Hot; M Kirchengast; H J Buhr
Journal:  J Gastrointest Surg       Date:  1998 Jul-Aug       Impact factor: 3.452

10.  Roles of endothelin-1 and nitric oxide in the mechanism for ethanol-induced vasoconstriction in rat liver.

Authors:  M Oshita; Y Takei; S Kawano; H Yoshihara; T Hijioka; H Fukui; M Goto; E Masuda; Y Nishimura; H Fusamoto
Journal:  J Clin Invest       Date:  1993-04       Impact factor: 14.808
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