Literature DB >> 6835360

A transcriptional function for the repetitive ribosomal spacer in Xenopus laevis.

T Moss.   

Abstract

The function of the Xenopus laevis ribosomal spacer has been studied in vivo and by microinjection of in vitro mutants into Xenopus oocytes. It is shown that the spacer directs specific RNA transcripts which most probably terminate upstream of the ribosomal genes and that it is able to modulate transcription of these genes. The data lead to a model in which the ribosomal spacer is a loading site for RNA polymerase I and spacer transcription is the driving force by which polymerase is delivered to the ribosomal gene promoter.

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Year:  1983        PMID： 6835360     DOI： 10.1038/302223a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  110 in total

Review 1.  Nucleolar dominance: uniparental gene silencing on a multi-megabase scale in genetic hybrids.

Authors:  C S Pikaard
Journal:  Plant Mol Biol       Date:  2000-06       Impact factor: 4.076

2.  Characterization of two types of ribosomal gene transcription in Xenopus laevis oocytes.

Authors:  P Labhart
Journal:  Gene Expr       Date:  1992

3.  Transcription and tyranny in the nucleolus: the organization, activation, dominance and repression of ribosomal RNA genes.

Authors:  Craig S Pikaard
Journal:  Arabidopsis Book       Date:  2002-08-12

4.  Spacer promoters are orientation-dependent activators of pre-rRNA transcription in Drosophila melanogaster.

Authors:  G Grimaldi; P Fiorentini; P P Di Nocera
Journal:  Mol Cell Biol       Date:  1990-09       Impact factor: 4.272

5.  Sequences within the spacer region of yeast rRNA cistrons that stimulate 35S rRNA synthesis in vivo mediate RNA polymerase I-dependent promoter and terminator activities.

Authors:  R Mestel; M Yip; J P Holland; E Wang; J Kang; M J Holland
Journal:  Mol Cell Biol       Date:  1989-03       Impact factor: 4.272

6.  Ribosomal gene promoter domains can function as artificial enhancers of RNA polymerase I transcription, supporting a promoter origin for natural enhancers in Xenopus.

Authors:  C S Pikaard
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

7.  Accurate and efficient transcription of human c-myc genes injected into Xenopus laevis oocytes.

Authors:  K Nishikura; S Goldflam; G A Vuocolo
Journal:  Mol Cell Biol       Date:  1985-06       Impact factor: 4.272

8.  Nucleotides flanking the promoter sequence influence the transcription of the yeast mitochondrial gene coding for ATPase subunit 9.

Authors:  T K Biswas; G S Getz
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

9.  Transcription in cloned spacers of Xenopus laevis ribosomal DNA.

Authors:  G T Morgan; R H Reeder; A H Bakken
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

10.  Two distant and precisely positioned domains promote transcription of Xenopus laevis rRNA genes: analysis with linker-scanning mutants.

Authors:  J J Windle; B Sollner-Webb
Journal:  Mol Cell Biol       Date:  1986-12       Impact factor: 4.272
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