Literature DB >> 6834396

Antimycotic azoles. 6. Synthesis and antifungal properties of terconazole, a novel triazole ketal.

J Heeres, R Hendrickx, J Van Cutsem.   

Abstract

The preparation and antifungal properties of cis-1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1, 3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)piperazine are reported. Terconazole has a high topical in vivo activity against vaginal candidosis in rats and against dermatophytosis in guinea pigs.

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Year:  1983        PMID： 6834396     DOI： 10.1021/jm00358a032

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  10 in total

Review 1.  Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches.

Authors:  Pedro N Batalha; Luana S M Forezi; Carolina G S Lima; Fernanda P Pauli; Fernanda C S Boechat; Maria Cecília B V de Souza; Anna C Cunha; Vitor F Ferreira; Fernando de C da Silva
Journal:  Bioorg Chem       Date:  2020-11-19       Impact factor: 5.275

Review 2.  An overview of topical antifungal therapy in dermatomycoses. A North American perspective.

Authors:  A K Gupta; T R Einarson; R C Summerbell; N H Shear
Journal:  Drugs       Date:  1998-05       Impact factor: 9.546

Review 3.  Overview of medically important antifungal azole derivatives.

Authors:  R A Fromtling
Journal:  Clin Microbiol Rev       Date:  1988-04       Impact factor: 26.132

4.  Comparison of the in vitro and in vivo activity of the bis-triazole derivative UK 49,858 with that of amphotericin B against Histoplasma capsulatum.

Authors:  G S Kobayashi; S Travis; G Medoff
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

5.  PLGA-modified Syloid®-based microparticles for the ocular delivery of terconazole: in-vitro and in-vivo investigations.

Authors:  Nada Zaghloul; Azza A Mahmoud; Nermeen A Elkasabgy; Nada M El Hoffy
Journal:  Drug Deliv       Date:  2022-12       Impact factor: 6.819

6.  Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51).

Authors:  Andrew G S Warrilow; Claire M Hull; Nicola J Rolley; Josie E Parker; W David Nes; Stephen N Smith; Diane E Kelly; Steven L Kelly
Journal:  Appl Environ Microbiol       Date:  2014-08-01       Impact factor: 4.792

Review 7.  Drug strategies targeting CYP51 in neglected tropical diseases.

Authors:  Jun Yong Choi; Larissa M Podust; William R Roush
Journal:  Chem Rev       Date:  2014-10-22       Impact factor: 60.622

8.  Synthesis, Characterization and Antibacterial Activity of some Novel Thiosemicarbazides, 1,2,4-Triazol-3-thiols and their S-substituted Derivatives.

Authors:  Mehdi Kalhor; Mahboobeh Shabani; Iraj Nikokar; Seyedeh Reyhaneh Banisaeed
Journal:  Iran J Pharm Res       Date:  2015       Impact factor: 1.696

Review 9.  Conazoles.

Authors:  Jan Heeres; Lieven Meerpoel; Paul Lewi
Journal:  Molecules       Date:  2010-06-09       Impact factor: 4.411

Review 10.  Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors.

Authors:  David J Leaver
Journal:  Molecules       Date:  2018-07-17       Impact factor: 4.411
  10 in total

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