Literature DB >> 6834392

2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogues.

A A Deana, G E Stokker, E M Schultz, R L Smith, E J Cragoe, H F Russo, L S Watson.   

Abstract

A number of bicyclic ring-fused analogues of 2-(aminomethyl)phenol were synthesized and tested orally in rats and intravenously in dogs for saluretic and diuretic effects. Of the 15 alicylic, aromatic, and heterocyclic ring-fused compounds tested, only 2-(aminomethyl)-4-chloro-1-naphthalenol hydrochloride (2) and 7-(aminomethyl)-6-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydronaphthalene hydrochloride (6) displayed a high order of activity.

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Year:  1983        PMID： 6834392     DOI： 10.1021/jm00358a023

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

1.  Novel coumarin-based tyrosinase inhibitors discovered by OECD principles-validated QSAR approach from an enlarged, balanced database.

Authors:  Huong Le-Thi-Thu; Gerardo M Casañola-Martín; Yovani Marrero-Ponce; Antonio Rescigno; Luciano Saso; Virinder S Parmar; Francisco Torrens; Concepción Abad
Journal:  Mol Divers       Date:  2010-09-03       Impact factor: 2.943

2.  Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.

Authors:  J C Bressi; C L Verlinde; A M Aronov; M L Shaw; S S Shin; L N Nguyen; S Suresh; F S Buckner; W C Van Voorhis; I D Kuntz; W G Hol; M H Gelb
Journal:  J Med Chem       Date:  2001-06-21       Impact factor: 7.446

Review 3.  Furo[3,2-c]coumarins carrying carbon substituents at C-2 and/or C-3. Isolation, biological activity, synthesis and reaction mechanisms.

Authors:  Iván Cortés; L Javier Cala; Andrea B J Bracca; Teodoro S Kaufman
Journal:  RSC Adv       Date:  2020-09-10       Impact factor: 4.036
  3 in total

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