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Literature DB >> 683303

Neoplastic transformation induced by a direct perturbation of DNA.

Abstract

Treatment of Syrian hamster embryo cells with 5-bromodeoxyuridine followed by near ultraviolet irradiation results in neoplastic transformation of these cells. This demonstrates that a direct perturbation of DNA is sufficient to initiate neoplastic transformation.

Entities: Chemical Disease Species

Mesh：

Substances：
DNA
Bromodeoxyuridine

Year: 1978 PMID： 683303 DOI： 10.1038/274229a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

11 in total

1. Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.

Authors: C Shih; B Z Shilo; M P Goldfarb; A Dannenberg; R A Weinberg
Journal: Proc Natl Acad Sci U S A Date: 1979-11 Impact factor: 11.205

2. Chemical carcinogens produce mutations to ouabain resistance in transformable C3H/10T1/2 Cl 8 mouse fibroblasts.

Authors: J R Landolph; C Heidelberger
Journal: Proc Natl Acad Sci U S A Date: 1979-02 Impact factor: 11.205

3. Focus formation and neoplastic transformation by herpes simplex virus type 2 inactivated intracellularly by 5-bromo-2'-deoxyuridine and near UV light.

Authors: M M Manak; L Aurelian; P O Ts'o
Journal: J Virol Date: 1981-10 Impact factor: 5.103

4. Differential cell cycle phase specificity for neoplastic transformation and mutation to ouabain resistance induced by N-methyl-N'-nitro-N-nitrosoguanidine in synchronized C3H10T 1/2 C18 cells.

Authors: P J McCormick; J S Bertram
Journal: Proc Natl Acad Sci U S A Date: 1982-07 Impact factor: 11.205

Neoplastic transformation induced by a direct perturbation of DNA.

1. Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.

2. Chemical carcinogens produce mutations to ouabain resistance in transformable C3H/10T1/2 Cl 8 mouse fibroblasts.

3. Focus formation and neoplastic transformation by herpes simplex virus type 2 inactivated intracellularly by 5-bromo-2'-deoxyuridine and near UV light.

4. Differential cell cycle phase specificity for neoplastic transformation and mutation to ouabain resistance induced by N-methyl-N'-nitro-N-nitrosoguanidine in synchronized C3H10T 1/2 C18 cells.

5. Chemical carcinogens transform BHK cells by inducing a recessive mutation.

6. Neoplastic conversion of preneoplastic Syrian hamster cells: rate estimation by fluctuation analysis.

7. Presidential address. Recent concepts of initiation and promotion in carcinogenesis.

8. Identification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells.

9. Malignant transformation induced by incorporated radionuclides in BALB/3T3 mouse embryo fibroblasts.

10. Bromodeoxyuridine in tumors and chromosomes detected with a monoclonal antibody.