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Literature DB >> 6832488

Spontaneous diabetes mellitus in the BB/W rat. Effects of glucocorticoids, cyclosporin-A, and antiserum to rat lymphocytes.

A A Like, M Anthony, D L Guberski, A A Rossini.

Abstract

Combination immunosuppression therapy with long-acting glucocorticoids, cyclosporin-A, and antiserum to rat lymphocytes (ALS) reduced the severity of spontaneous diabetes among BioBreeding/Worcester rats and decreased the frequency of diabetes in susceptible littermates. Combination therapy with glucocorticoids and three injections of ALS reversed hyperglycemia in a significant number of acutely diabetic animals. These results strengthen the hypothesis that autoimmunity plays a role in the pathogenesis of diabetes in these animals and increase our understanding of the requirements of treatment protocols for the prevention and cure of this spontaneous syndrome.

Entities: Chemical Disease Species

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Year: 1983 PMID： 6832488 DOI： 10.2337/diab.32.4.326

Source DB: PubMed Journal: Diabetes ISSN： 0012-1797 Impact factor: 9.461

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Cited

20 in total

1. A delayed-type hypersensitivity skin-test system using the insulinoma cell line RINm5F to monitor beta cell-specific cellular autoimmune reactivity in the spontaneously diabetic BB/O rat.

Authors: H A Voorby; P H Jeucken; H A Drexhage
Journal: Clin Exp Immunol Date: 1990-12 Impact factor: 4.330

2. Diabetes mellitus in the BB/W rat. Insulitis in pancreatic islet grafts after transplantation in diabetic recipients.

Authors: E J Weringer; A A Like
Journal: Am J Pathol Date: 1986-10 Impact factor: 4.307

Review 3. The epidemiology of diabetes in childhood with special reference to the Orient: implications for mechanism of beta cell damage.

Authors: A L Drash; N Cho; N Tajima; M Rewers; R Laporte
Journal: Indian J Pediatr Date: 1989 Nov-Dec Impact factor: 1.967

10. Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats.

Authors: E J Weringer; A A Like
Journal: Am J Pathol Date: 1988-08 Impact factor: 4.307

Spontaneous diabetes mellitus in the BB/W rat. Effects of glucocorticoids, cyclosporin-A, and antiserum to rat lymphocytes.

1. A delayed-type hypersensitivity skin-test system using the insulinoma cell line RINm5F to monitor beta cell-specific cellular autoimmune reactivity in the spontaneously diabetic BB/O rat.

2. Diabetes mellitus in the BB/W rat. Insulitis in pancreatic islet grafts after transplantation in diabetic recipients.

Review 3. The epidemiology of diabetes in childhood with special reference to the Orient: implications for mechanism of beta cell damage.

Review 4. Polyglandular autoimmune syndrome: current concepts.

5. Prevention of diabetes mellitus in the BB/W rat with Cyclosporin-A.

6. Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.

7. WIN 54954 treatment of mice infected with a diabetogenic strain of group B coxsackievirus.

8. Longitudinal study of first phase insulin release in the BB rat.

Review 9. Treatment of type 1 diabetes with anti-T-cell agents: from T-cell depletion to T-cell regulation.

10. Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats.