Literature DB >> 6832322

Effect of dimethindene, an antihistaminic drug, on the transmembrane potentials of mammalian myocardium.

J Mészáros, E Hlavacsek-Póka, J Szegi.   

Abstract

Dimethindene (DMI) decreased the maximum rate of rise of action potential (AP) without changing the resting potential in cat ventricular myocardium. DMI abolished the histamine-induced slow APs in left atria but not in right ventricular papillary muscles of guinea-pig, suggesting that DMI blocked the histamine H1-receptors.

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Year:  1983        PMID： 6832322     DOI： 10.1007/bf01963146

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Slow Ca2+ and Na+ responses induced by isoproterenol and methylxanthines in isolated perfused guinea pig hearts exposed to elevated K+.

Authors:  J A Schneider; N Sperelakis
Journal:  J Mol Cell Cardiol       Date:  1975-04       Impact factor: 5.000

2.  Influence of H1- and H2-receptor antagonists on the circulatory system and on the endogenous plasma histamine concentrations in dogs.

Authors:  M Thermann; W Lorenz; A Schmal; F Schingale; P Dormann; H Hamelmann
Journal:  Agents Actions       Date:  1977-03

3.  Restorative effect of histamine on the transmembrane action potentials in potassium-depolarized guinea-pig auricle.

Authors:  V Kecskeméti
Journal:  Pol J Pharmacol Pharm       Date:  1978 Mar-Jun

Review 4.  Cardiac histamine receptors.

Authors:  R Levi; G Allan; J H Zavecz
Journal:  Fed Proc       Date:  1976-06

Review 5.  Ionic mechanisms in heart muscle in relation to the genesis and the pharmacological control of cardiac arrhythmias.

Authors:  O Hauswirth; B N Singh
Journal:  Pharmacol Rev       Date:  1978-03       Impact factor: 25.468

Review 6.  Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels.

Authors:  L M Hondeghem; B G Katzung
Journal:  Biochim Biophys Acta       Date:  1977-11-14

7.  Calcium-dependent action potentials produced by catecholamines in guinea pig atrial muscle fibers depolarized by potassium.

Authors:  A J Pappano
Journal:  Circ Res       Date:  1970-09       Impact factor: 17.367

8.  Mechanism of the histamine-induced positive inotropic action in cardiac muscle.

Authors:  I Josephson; J F Renaud; S Vogel; M Mclean; N Sperelakis
Journal:  Eur J Pharmacol       Date:  1976-02       Impact factor: 4.432

9.  A pharmacologic investigation of dimethpyrindene maleate (Forhistal).

Authors:  W E BARRETT; C F HUEBNER; R A RUTLEDGE; A DEITRICH; A J PLUMMER
Journal:  Toxicol Appl Pharmacol       Date:  1961-09       Impact factor: 4.219

10.  Effect of dantrolene sodium on the transmembrane potentials and contractility of guinea pig atrial myocardium.

Authors:  J Mészáros; V Kecskeméti; J Szegi
Journal:  Eur J Pharmacol       Date:  1981-09-11       Impact factor: 4.432
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  3 in total

1.  Electrophysiological actions of histamine and H1-, H2-receptor antagonists in cardiac tissue.

Authors:  U Borchard; D Hafner; C Hirth
Journal:  Agents Actions       Date:  1986-04

2.  Electrophysiological characterization of histamine receptor subtypes in mammalian heart preparations.

Authors:  U Borchard; D Hafner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-11       Impact factor: 3.000

3.  Blockage of the fast sodium current by dimethindene in frog auricular fibres.

Authors:  J Mészáros; R Markó; K Kelemen; V Kecskeméti
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-03       Impact factor: 3.000
  3 in total

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