Mediastinal angiofollicular lymph node hyperplasia with systemic manifestations.

This case report concerns a 19-year-old girl with a mediastinal angiofollicular lymph node hyperplasia (Castleman tumour), with histological aspects of both hyalin vascular and plasma cell type. Systemic manifestations were also noticed. A lymphocytic infiltration of the bone marrow and a change in the lactic dehydrogenase iso-enzyme pattern with an increase of LDH3 were noted. After surgical removal of the mediastinal tumour complete recovery and normalisation of biological abnormalities occurred.