Motor aspects of cue-related neuronal activity in premotor cortex of the rhesus monkey.

Neurons in the premotor cortex of rhesus monkeys were studied under two conditions: (1) visuospatial cues were given to guide the amplitude, direction, and onset time of forearm movements or (2) physically identical visual cues were given when reward was contingent on withholding movement. Neurons with sustained activity following the cues were preferentially active when the cues triggered a movement. Thus, activity of certain neurons in this cortical field is linked to motor set, i.e. intention to make a movement in response to the cue, rather than the visual cue per se.