[The role of lysozyme and peroxidase in the regulation of the mitogenic activity of lymphocytes].

The effect of the commercial preparations, egg white lysozyme and horse-radish peroxidase, as well as that of purified enzymes isolated from human saliva on lymphocyte biosynthesis of nucleic acids and protein was studied. Mitogenic activity of lymphocytes was found to be stimulated by crude preparations of egg white lysozyme and peroxidases of plant and animal origin. Lysozymes of the saliva and egg white purified by ion exchange chromatography and gel filtration had no such properties. As a result of egg white gel filtration, a new mitogen of the non-protein nature with a molecular weight several times higher than that of lysozyme was obtained.