Literature DB >> 6830183

No effect from double-blind trial of physostigmine and lecithin in Alzheimer disease.

A Wettstein.   

Abstract

Eight patients with clinically diagnosed mild to severe Alzheimer disease were treated during two six-week periods by a double-blind, single-crossover protocol with placebo or a combination of 18 gm of lecithin and 3 to 10 mg of oral physostigmine daily. No improvement in behavior, recent memory, or other neuropsychological functions occurred.

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Year:  1983        PMID: 6830183     DOI: 10.1002/ana.410130220

Source DB:  PubMed          Journal:  Ann Neurol        ISSN: 0364-5134            Impact factor:   10.422


  7 in total

1.  Effects of physostigmine on stimulus encoding in a memory-scanning task.

Authors:  A Wetherell
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

Review 2.  Neurochemical aspects of Alzheimer's disease: involvement of membrane phospholipids.

Authors:  A A Farooqui; L Liss; L A Horrocks
Journal:  Metab Brain Dis       Date:  1988-03       Impact factor: 3.584

Review 3.  Physostigmine for Alzheimer's disease.

Authors:  F Coelho; J Birks
Journal:  Cochrane Database Syst Rev       Date:  2001

Review 4.  Critical review of clinical trials in senile dementia--II.

Authors:  J M Orgogozo; R Spiegel
Journal:  Postgrad Med J       Date:  1987-05       Impact factor: 2.401

5.  Cholinergic treatment of an amnestic man with a basal forebrain lesion: theoretical implications.

Authors:  A Chatterjee; M K Morris; D Bowers; D J Williamson; L Doty; K M Heilman
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-12       Impact factor: 10.154

Review 6.  Hormesis and medicine.

Authors:  Edward J Calabrese
Journal:  Br J Clin Pharmacol       Date:  2008-06-28       Impact factor: 4.335

Review 7.  Advances in the pharmacotherapy of Alzheimer's disease.

Authors:  J C Soares; S Gershon
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1994       Impact factor: 5.270

  7 in total

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