Literature DB >> 6829074

Immunosuppressive effect of bredinin on cell-mediated and humoral immune reactions in experimental animals.

K Kamata, M Okubo, E Ishigamori, Y Masaki, H Uchida, K Watanabe, N Kashiwagi.   

Abstract

Bredinin (BR), an imidazole nucleoside isolated from Eupenicillium brefeldianum was previously reported to prolong kidney allograft survival in dogs. The immunosuppressive effect of BR was studied in experimental animals. In beagles, in vitro responses of lymphocytes stimulated by mitogens or allogeneic cells were suppressed by in vitro BR treatment. BR, given in vivo, also showed an inhibitory action against development of delayed hypersensitivity reaction to tubercle bacilli in guinea pigs or against hemagglutinin production following booster SRBC injection in rabbits. Of note may be the fact that BR was found to have an immunosuppressive potency comparable to that of azathioprine and, in addition, to show a decreased hepatotoxicity compared with the latter.

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Year:  1983        PMID： 6829074     DOI： 10.1097/00007890-198302000-00007

Source DB:  PubMed          Journal:  Transplantation        ISSN： 0041-1337            Impact factor:   4.939


  9 in total

1.  High-dose mizoribine therapy for childhood-onset frequently relapsing steroid-dependent nephrotic syndrome with cyclosporin nephrotoxicity.

Authors:  Yoshiyuki Ohtomo; Shu-ichiro Fujinaga; Masaru Takada; Hitohiko Murakami; Shunji Akashi; Toshiaki Shimizu; Kazunari Kaneko; Yuichiro Yamashiro
Journal:  Pediatr Nephrol       Date:  2005-08-20       Impact factor: 3.714

2.  Prevention of spontaneous and cyclophosphamide-induced diabetes in non-obese diabetic (NOD) mice with oral 2-acetyl-4-tetrahydroxybutylimidazole (THI), a component of caramel colouring III.

Authors:  T E Mandel; M Koulmanda; I R Mackay
Journal:  Clin Exp Immunol       Date:  1992-06       Impact factor: 4.330

3.  Combination therapy with mizoribine for severe childhood IgA nephropathy: a pilot study.

Authors:  Norishige Yoshikawa; Koichi Nakanishi; Kenji Ishikura; Hiroshi Hataya; Kazumoto Iijima; Masataka Honda
Journal:  Pediatr Nephrol       Date:  2008-01-26       Impact factor: 3.714

4.  Rat lymphoid cell lines with HTLV-I production. III. Transmission of HTLV-I into rats and analysis of cell surface antigens associated with HTLV-I.

Authors:  T Yoshiki; N Kondo; T Chubachi; M Tateno; T Togashi; T Itoh
Journal:  Arch Virol       Date:  1987       Impact factor: 2.574

Review 5.  Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story.

Authors:  Rand Naffouje; Punita Grover; Hongyang Yu; Arun Sendilnathan; Kara Wolfe; Nazanin Majd; Eric P Smith; Koh Takeuchi; Toshiya Senda; Satoshi Kofuji; Atsuo T Sasaki
Journal:  Cancers (Basel)       Date:  2019-09-11       Impact factor: 6.639

Review 6.  Mizoribine: a new approach in the treatment of renal disease.

Authors:  Yukihiko Kawasaki
Journal:  Clin Dev Immunol       Date:  2009-12-13

7.  Involvement of Multiple Transporters-mediated Transports in Mizoribine and Methotrexate Pharmacokinetics.

Authors:  Teruo Murakami; Nobuhiro Mori
Journal:  Pharmaceuticals (Basel)       Date:  2012-08-10

8.  Characterization of a fungicidal substance produced by Eupenicillium brefeldianum isolated from soil for plant disease control and its significance in nature.

Authors:  Yen-Ting Chen; Wen-Hsiung Ko
Journal:  Bot Stud       Date:  2014-07-22       Impact factor: 2.787

Review 9.  14-3-3: A Case Study in PPI Modulation.

Authors:  Alice Ballone; Federica Centorrino; Christian Ottmann
Journal:  Molecules       Date:  2018-06-08       Impact factor: 4.411
  9 in total

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