| Literature DB >> 6829050 |
P M Foster, L V Thomas, M W Cook, D G Walters.
Abstract
Treatment of young male rats with dipentyl phthalate (DPP) produced significant decreases in testicular cytochrome P-450, cytochrome P-450 dependent microsomal steroidogenic enzymes (17 alpha-hydroxylase, 17-20 lyase) and in the maximal binding of a natural substrate (progesterone) to testis microsomes. No effect was demonstrated by this compound on hepatic cytochrome P-450 content. Treatment of animals with a phthalate ester not causing testicular atrophy (diethyl phthalate; DEP) produced no significant changes in any of the parameters measured. This effect on the enzymes responsible for androgen production may be important as a mechanism of action involved in the development of phthalate-induced testicular damage.Entities:
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Year: 1983 PMID： 6829050 DOI： 10.1016/0378-4274(83)90226-6
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372