Literature DB >> 6828884

Tumor promotion by phorbol esters in skin: evidence for a memory effect.

G Fürstenberger, B Sorg, F Marks.   

Abstract

By means of a two-stage promotion protocol in mouse epidermis with 12-O-tetradecanoylphorbol-13-acetate as first-stage promoter and 12-O-retinoylphorbol-13-acetate as second-stage promoter, the effects of the former that are critical and obligatory for tumor promotion were shown to be irreversible in nature for at least 8 weeks. The reversibility of tumor promotion was related to the second stage of promotion, reflecting the reversibility of epidermal hyperplasia induced by 12-O-tetradecanoylphorbol-13-acetate.

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Year:  1983        PMID： 6828884     DOI： 10.1126/science.6828884

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Early changes in the arachidonic acid metabolism of HeLa cells in response to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and related compounds.

Authors:  U Espe; G Fürstenberger; F Marks; M Kaszkin; V Kinzel
Journal:  J Cancer Res Clin Oncol       Date:  1987       Impact factor: 4.553

2.  Suppression of the first stage of phorbol 12-tetradecanoate 13-acetate-effected tumor promotion in mouse skin by nontoxic inhibition of DNA synthesis.

Authors:  V Kinzel; H Loehrke; K Goerttler; G Fürstenberger; F Marks
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

3.  Tumour promoters but not initiators deplete Langerhans cells from murine epidermis.

Authors:  G M Halliday; G R MacCarrick; H K Muller
Journal:  Br J Cancer       Date:  1987-09       Impact factor: 7.640

Review 4.  Oxidation of DNA bases by tumor promoter-activated processes.

Authors:  K Frenkel
Journal:  Environ Health Perspect       Date:  1989-05       Impact factor: 9.031

Review 5.  Perspectives on the risk assessment for nongenotoxic carcinogens and tumor promoters.

Authors:  F P Perera
Journal:  Environ Health Perspect       Date:  1991-08       Impact factor: 9.031

Review 6.  Defective responses of transformed keratinocytes to terminal differentiation stimuli. Their role in epidermal tumour promotion by phorbol esters and by deep skin wounding.

Authors:  E K Parkinson
Journal:  Br J Cancer       Date:  1985-10       Impact factor: 7.640

7.  Low dose triterpene-quinone fraction from Ardisia crispa root precludes chemical-induced mouse skin tumor promotion.

Authors:  Looi Ting Yeong; Roslida Abdul Hamid; Latifah Saiful Yazan; Huzwah Khaza'ai; Norhafizah Mohtarrudin
Journal:  BMC Complement Altern Med       Date:  2015-12-05       Impact factor: 3.659
  7 in total

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