Literature DB >> 6827986

Formation of beta-hydroxyisovalerate by an alpha-ketoisocaproate oxygenase in human liver.

P J Sabourin, L L Bieber.   

Abstract

Previously we demonstrated the occurrence of a soluble dioxygenase in rat liver which converts alpha-ketoisocaproic acid (the keto acid analog of leucine) to beta-hydroxyisovaleric acid. Herein we show that human liver contains a similar soluble enzyme which converts alpha-ketoisocaproate to beta-hydroxisovaleric acid. We suggest this enzyme functions as a "safety valve" in liver to help prevent excessive accumulation of alpha-ketoisocaproate.

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Year:  1983        PMID： 6827986     DOI： 10.1016/0026-0495(83)90223-8

Source DB:  PubMed          Journal:  Metabolism        ISSN： 0026-0495            Impact factor:   8.694


  9 in total

1.  Enteral β-hydroxy-β-methylbutyrate supplementation increases protein synthesis in skeletal muscle of neonatal pigs.

Authors:  Michelle Kao; Daniel A Columbus; Agus Suryawan; Julia Steinhoff-Wagner; Adriana Hernandez-Garcia; Hanh V Nguyen; Marta L Fiorotto; Teresa A Davis
Journal:  Am J Physiol Endocrinol Metab       Date:  2016-05-03       Impact factor: 4.310

2.  Determination of β-hydroxy-β-methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry.

Authors:  Dillon K Walker; John J Thaden; Agata Wierzchowska-McNew; Marielle P K J Engelen; Nicolaas E P Deutz
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2016-11-09       Impact factor: 3.205

3.  Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of β-hydroxy-β-methylbutyrate.

Authors:  Scott M Wheatley; Samer W El-Kadi; Agus Suryawan; Claire Boutry; Renán A Orellana; Hanh V Nguyen; Steven R Davis; Teresa A Davis
Journal:  Am J Physiol Endocrinol Metab       Date:  2013-11-05       Impact factor: 4.310

4.  Conversion of beta-methylbutyric acid to beta-hydroxy-beta-methylbutyric acid by Galactomyces reessii.

Authors:  I Y Lee; S L Nissen; J P Rosazza
Journal:  Appl Environ Microbiol       Date:  1997-11       Impact factor: 4.792

5.  β-Hydroxy-β-methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway.

Authors:  Gustavo D Pimentel; José C Rosa; Fábio S Lira; Nelo E Zanchi; Eduardo R Ropelle; Lila M Oyama; Cláudia M Oller do Nascimento; Marco Túlio de Mello; Sergio Tufik; Ronaldo Vt Santos
Journal:  Nutr Metab (Lond)       Date:  2011-02-23       Impact factor: 4.169

6.  A metabolite of leucine (β-hydroxy-β-methylbutyrate) given to sows during pregnancy alters bone development of their newborn offspring by hormonal modulation.

Authors:  Tomasz Blicharski; Ewa Tomaszewska; Piotr Dobrowolski; Monika Hułas-Stasiak; Siemowit Muszyński
Journal:  PLoS One       Date:  2017-06-15       Impact factor: 3.240

7.  Isobutene production in Synechocystis sp. PCC 6803 by introducing α-ketoisocaproate dioxygenase from Rattus norvegicus.

Authors:  Henna Mustila; Amit Kugler; Karin Stensjö
Journal:  Metab Eng Commun       Date:  2021-01-23

8.  Simultaneous quantification of salivary 3-hydroxybutyrate, 3-hydroxyisobutyrate, 3-hydroxy-3-methylbutyrate, and 2-hydroxybutyrate as possible markers of amino acid and fatty acid catabolic pathways by LC-ESI-MS/MS.

Authors:  Teruo Miyazaki; Akira Honda; Tadashi Ikegami; Junichi Iwamoto; Tadakuni Monma; Takeshi Hirayama; Yoshifumi Saito; Kouwa Yamashita; Yasushi Matsuzaki
Journal:  Springerplus       Date:  2015-09-15

Review 9.  A Review of the Effects of Leucine Metabolite (β-Hydroxy-β-methylbutyrate) Supplementation and Resistance Training on Inflammatory Markers: A New Approach to Oxidative Stress and Cardiovascular Risk Factors.

Authors:  Hamid Arazi; Behzad Taati; Katsuhiko Suzuki
Journal:  Antioxidants (Basel)       Date:  2018-10-20
  9 in total

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