Literature DB >> 6827901

Evidence for the presence of enkephalins in the heart.

R E Lang, K Hermann, R Dietz, W Gaida, D Ganten, K Kraft, T Unger.   

Abstract

Extracts of guinea pig hearts were subjected to high performance liquid chromatography (HPLC) and the eluted fractions monitored by radioimmunoassays (RIA) for their content of leucine5-enkephalin (Leu-ENK) and methionine5 enkephalin (Met-ENK). Distinct peaks of both Leu-ENK and Met-ENK immunoreactivity were found corresponding to the position of synthetic Leu-ENK and Met-ENK respectively. The ratio of Leu-ENK to Met-ENK content was about 1:4. Chemical sympathectomy with 5-hydroxydopamine (6-OH-DA) produced a dramatic fall in noradrenaline content of the heart by more than 99%, whereas the concentration in Leu-ENK was reduced by only 70%. The Leu-ENK content of the adrenal glands was not affected by this treatment. These observations point to an enkephalinergic innervation of the heart which appears to be mainly of sympathetic origin. The results suggest the participation of enkephalins in cardiac reflex mechanisms.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6827901     DOI： 10.1016/0024-3205(83)90086-3

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  22 in total

1.  Effect of dynorphin A(1-13) on cardiomyocytes in culture: modulation of the response to increased extracellular calcium, but no effect on intrinsic cardiac contractile frequency or the response to isoproterenol or increased extracellular potassium.

Authors:  S W Rabkin
Journal:  Basic Res Cardiol       Date:  1992 May-Jun       Impact factor: 17.165

2.  Failure of opioids to affect excitation and contraction in isolated ventricular heart muscle.

Authors:  H Nawrath; J Rupp; H Jakob; U Sack; F Mertzlufft; W Dick
Journal:  Experientia       Date:  1989-04-15

3.  Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma.

Authors:  F Niroomand; R A Mura; L Piacentini; W Kübler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-11       Impact factor: 3.000

4.  Influence of naloxone on the effects of high frequency transcutaneous electrical nerve stimulation in angina pectoris induced by atrial pacing.

Authors:  C Mannheimer; H Emanuelsson; F Waagstein; C Wilhelmsson
Journal:  Br Heart J       Date:  1989-07

5.  Correlation of neuronal size and peptide immunoreactivity in the guinea-pig trigeminal ganglion.

Authors:  W Kummer; C Heym
Journal:  Cell Tissue Res       Date:  1986       Impact factor: 5.249

6.  Enkephalins increase cyclic adenosine monophosphate content, calcium uptake, and contractile state in cultured chick embryo heart cells.

Authors:  S Laurent; J D Marsh; T W Smith
Journal:  J Clin Invest       Date:  1986-05       Impact factor: 14.808

7.  Proenkephalin mRNA in rat heart.

Authors:  R D Howells; D L Kilpatrick; L C Bailey; M Noe; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

8.  Influence of endogenous opioids on atrial natriuretic factor release during exercise in man.

Authors:  F Louisy; C Y Guezennec; M Lartigue; J C Aldigier; F X Galen
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1989

9.  Influence of the optical isomers (+)- and (-)-naloxone on beating frequency, contractile force and action potentials of guinea-pig isolated cardiac preparations.

Authors:  H Brasch
Journal:  Br J Pharmacol       Date:  1986-08       Impact factor: 8.739

10.  Determination of infundibular innervation and amine receptor content in cyanotic and acyanotic myocardium: relation to clinical events in tetralogy of Fallot.

Authors:  L B McGrath; C Chen; J Gu; J Bianchi; J M Levett
Journal:  Pediatr Cardiol       Date:  1991-07       Impact factor: 1.655
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.