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Literature DB >> 6827249

Molecular basis of rabies virus virulence. II. Identification of a site on the CVS glycoprotein associated with virulence.

Abstract

Nine anti-G monoclonal antibodies were used to select mutants of the CVS strain of rabies virus resistant to neutralization. Seven mutants were avirulent in adult mice and two others exhibited an attenuated pathogenicity. Both categories were resistant to monoclonal antibodies 194-2 and 248-8. Virulence appears to be associated with a particular configuration of a region of the glycoprotein which is located at the intersection of the epitopes recognized by these two monoclonal antibodies. Our results confirm the role played by the glycoprotein in the neurovirulence of rabies virus.

Entities: Disease Species

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Year: 1983 PMID： 6827249 DOI： 10.1099/0022-1317-64-3-693

Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891

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Cited

17 in total

1. Antigenicity of rabies virus glycoprotein.

Authors: A Benmansour; H Leblois; P Coulon; C Tuffereau; Y Gaudin; A Flamand; F Lafay
Journal: J Virol Date: 1991-08 Impact factor: 5.103

2. Folding of rabies virus glycoprotein: epitope acquisition and interaction with endoplasmic reticulum chaperones.

Authors: Y Gaudin
Journal: J Virol Date: 1997-05 Impact factor: 5.103

3. Characterization of a unique variant of bat rabies virus responsible for newly emerging human cases in North America.

Authors: K Morimoto; M Patel; S Corisdeo; D C Hooper; Z F Fu; C E Rupprecht; H Koprowski; B Dietzschold
Journal: Proc Natl Acad Sci U S A Date: 1996-05-28 Impact factor: 11.205

4. Rabies virulence: effect on pathogenicity and sequence characterization of rabies virus mutations affecting antigenic site III of the glycoprotein.

Authors: I Seif; P Coulon; P E Rollin; A Flamand
Journal: J Virol Date: 1985-03 Impact factor: 5.103

10. The glycoprotein and the matrix protein of rabies virus affect pathogenicity by regulating viral replication and facilitating cell-to-cell spread.

Authors: Rojjanaporn Pulmanausahakul; Jianwei Li; Matthias J Schnell; Bernhard Dietzschold
Journal: J Virol Date: 2007-12-19 Impact factor: 5.103

Molecular basis of rabies virus virulence. II. Identification of a site on the CVS glycoprotein associated with virulence.

1. Antigenicity of rabies virus glycoprotein.

2. Folding of rabies virus glycoprotein: epitope acquisition and interaction with endoplasmic reticulum chaperones.

3. Characterization of a unique variant of bat rabies virus responsible for newly emerging human cases in North America.

4. Rabies virulence: effect on pathogenicity and sequence characterization of rabies virus mutations affecting antigenic site III of the glycoprotein.

5. Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing).

6. Antigenic site II of the rabies virus glycoprotein: structure and role in viral virulence.

7. Pathways of the early propagation of virulent and avirulent rabies strains from the eye to the brain.

8. Nucleotide and deduced amino acid sequences of the glycoprotein gene of rabies virus vaccine strain Vnukovo-32.

Review 9. Everything You Always Wanted to Know About Rabies Virus (But Were Afraid to Ask).

10. The glycoprotein and the matrix protein of rabies virus affect pathogenicity by regulating viral replication and facilitating cell-to-cell spread.