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Literature DB >> 6826043

Vascular effects of ergot alkaloids: a study on human basilar arteries.

Abstract

Postmortem examinations on human basilar arteries were performed in vitro by recording isometric tension from spiral strips in tissue baths at 37 degrees C. Antagonism of 5-HT by ergotamine, dihydroergotamine and methysergide was of the non-competitive type, that of noradrenaline was either absent (i.e. ergotamine) or considerably weaker. In addition each ergot alkaloid acted as a partial agonist in the following order of efficacy: ergotamine greater than dihydroergotamine greater than methysergide, producing pD2 values of 9.30, 9.60 and 7.10 respectively. Evidence is provided that the stimulant activity of ergotamine is mediated through 5-HT receptors. The present results are compared to those obtained on isolated human vein strips as well as to those on canine blood vessels.

Entities: Chemical Species

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Year: 1983 PMID： 6826043 DOI： 10.1016/0306-3623(83)90073-3

Source DB: PubMed Journal: Gen Pharmacol ISSN： 0306-3623

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Cited

11 in total

1. Actions of non-peptide ergot alkaloids at 5-HT1-like and 5-HT2 receptors mediating vascular smooth muscle contraction.

Authors: S J MacLennan; G R Martin
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1990-08 Impact factor: 3.000

2. Contractile 5-HT1 receptors in human isolated pial arterioles: correlation with 5-HT1D binding sites.

Authors: E Hamel; D Bouchard
Journal: Br J Pharmacol Date: 1991-01 Impact factor: 8.739

3. Analysis of the heart rate effects of 5-hydroxytryptamine in the cat; mediation of tachycardia by 5-HT1-like receptors.

Authors: P R Saxena; E J Mylecharane; J Heiligers
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1985-08 Impact factor: 3.000

4. Effects of methysergide and 5-hydroxytryptamine on carotid blood flow distribution in pigs: further evidence for the presence of atypical 5-HT receptors.

Authors: P R Saxena; P D Verdouw
Journal: Br J Pharmacol Date: 1984-08 Impact factor: 8.739

5. The effects of nitroglycerin on exercise-induced regional myocardial contractile dysfunction are not diminished by pretreatment with dihydroergotamine.

Authors: W Schneider; G Krumpl; N Mayer; G Raberger
Journal: Br J Pharmacol Date: 1987-09 Impact factor: 8.739

10. Alpha-adrenoceptors, 5-hydroxytryptamine receptors and the action of dihydroergotamine in human venous preparations obtained during saphenectomy procedures for varicose veins.

Authors: E Müller-Schweinitzer
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1984-10 Impact factor: 3.000

Vascular effects of ergot alkaloids: a study on human basilar arteries.

1. Actions of non-peptide ergot alkaloids at 5-HT1-like and 5-HT2 receptors mediating vascular smooth muscle contraction.

2. Contractile 5-HT1 receptors in human isolated pial arterioles: correlation with 5-HT1D binding sites.

3. Analysis of the heart rate effects of 5-hydroxytryptamine in the cat; mediation of tachycardia by 5-HT1-like receptors.

4. Effects of methysergide and 5-hydroxytryptamine on carotid blood flow distribution in pigs: further evidence for the presence of atypical 5-HT receptors.

5. The effects of nitroglycerin on exercise-induced regional myocardial contractile dysfunction are not diminished by pretreatment with dihydroergotamine.

6. Effects of current and prospective antimigraine drugs on the porcine isolated meningeal artery.

Review 7. Clinical pharmacokinetics of ergotamine in migraine and cluster headache.

8. Influence of pizotifen and ergotamine on the venoconstrictor effect of 5-hydroxytryptamine and noradrenaline in man.

9. Mechanisms of the ergonovine-induced vasoconstriction in the rabbit main coronary artery.

10. Alpha-adrenoceptors, 5-hydroxytryptamine receptors and the action of dihydroergotamine in human venous preparations obtained during saphenectomy procedures for varicose veins.