Literature DB >> 6825977

Free and lipid inositol, sorbitol and sugars in sciatic nerve obtained post-mortem from diabetic patients and control subjects.

J A Mayhew, K R Gillon, J N Hawthorne.   

Abstract

Sciatic nerves removed post-mortem from diabetic patients and normal subjects were analysed by gas chromatography for glucose, fructose, sorbitol and myo-inositol. The concentrations of free and lipid inositol were significantly lower in nerves from the diabetic than from the control group. Concentrations of glucose, fructose and sorbitol were higher in the nerves of the diabetic patients.

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Year:  1983        PMID： 6825977     DOI： 10.1007/bf00275940

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  13 in total

1.  Peripheral nerves in early experimental diabetes: expansion of the endoneurial space as a cause of increased water content.

Authors:  J Jakobsen
Journal:  Diabetologia       Date:  1978-02       Impact factor: 10.122

2.  An accurate and rapid method for the determination of proteins in small amounts of blood serum and plasma.

Authors:  T E WEICHSELBAUM
Journal:  Am J Clin Pathol       Date:  1946-03       Impact factor: 2.493

Review 3.  Diabetic neuropathy--new concepts of its etiology.

Authors:  R S Clements
Journal:  Diabetes       Date:  1979-06       Impact factor: 9.461

4.  Phosphoinositide metabolism in rat superior cervical ganglion, vagus and phrenic nerve: effects of electrical stimulation and various blocking agents.

Authors:  G L White; H U Schellhase; J N Hawthorne
Journal:  J Neurochem       Date:  1974-01       Impact factor: 5.372

5.  Effect of blood sugar control on the accumulation of sorbitol and fructose in nervous tissues.

Authors:  J D Ward; R W Baker; B H Davis
Journal:  Diabetes       Date:  1972-12       Impact factor: 9.461

6.  Polyol accumulations in nervous tissue of rats with experimental diabetes and galactosaemia.

Authors:  M A Stewart; W R Sherman; M M Kurien; G I Moonsammy; M Wisgerhof
Journal:  J Neurochem       Date:  1967-11       Impact factor: 5.372

7.  Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes.

Authors:  D A Greene; P V De Jesus; A I Winegrad
Journal:  J Clin Invest       Date:  1975-06       Impact factor: 14.808

8.  Free and lipid myo-inositol in tissues from rats with acute and less severe streptozotocin-induced diabetes.

Authors:  K P Palmano; P H Whiting; J N Hawthorne
Journal:  Biochem J       Date:  1977-10-01       Impact factor: 3.857

9.  Nerve lipid abnormalities in human diabetic neuropathy: a correlative study.

Authors:  M J Brown; M Iwamori; Y Kishimoto; B Rapoport; H W Moser; A K Asbury
Journal:  Ann Neurol       Date:  1979-03       Impact factor: 10.422

10.  Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry.

Authors:  P J Dyck; W R Sherman; L M Hallcher; F J Service; P C O'Brien; L A Grina; P J Palumbo; C J Swanson
Journal:  Ann Neurol       Date:  1980-12       Impact factor: 10.422
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  22 in total

Review 1.  Aldose reductase inhibitors in the treatment of diabetic neuropathy. A review of the rationale and clinical evidence.

Authors:  E A Masson; A J Boulton
Journal:  Drugs       Date:  1990-02       Impact factor: 9.546

2.  Free inositol, sorbitol and fructose levels in sciatic nerve.

Authors:  W R Sherman; P J Dyck
Journal:  Diabetologia       Date:  1983-11       Impact factor: 10.122

3.  Role of sorbitol accumulation and myo-inositol depletion in paranodal swelling of large myelinated nerve fibers in the insulin-deficient spontaneously diabetic bio-breeding rat. Reversal by insulin replacement, an aldose reductase inhibitor, and myo-inositol.

Authors:  D A Greene; S Chakrabarti; S A Lattimer; A A Sima
Journal:  J Clin Invest       Date:  1987-05       Impact factor: 14.808

4.  Peripheral nerve function in relation to quality of metabolic control in diabetes.

Authors:  F W Bertelsmann; J J Heimans; J C van Rooy; C Popp-Snijders; E A van der Veen
Journal:  J Neurol       Date:  1987-06       Impact factor: 4.849

5.  myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment.

Authors:  C Popp-Snijders; M Z Lomecky-Janousek; J A Schouten; E A van der Veen
Journal:  Diabetologia       Date:  1984-11       Impact factor: 10.122

6.  Clinical and neurophysiological studies with the aldose reductase inhibitor, sorbinil, in symptomatic diabetic neuropathy.

Authors:  I G Lewin; I A O'Brien; M H Morgan; R J Corrall
Journal:  Diabetologia       Date:  1984-06       Impact factor: 10.122

7.  Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition.

Authors:  K R Gillon; J N Hawthorne; D R Tomlinson
Journal:  Diabetologia       Date:  1983-10       Impact factor: 10.122

8.  Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat.

Authors:  M J Stevens; S A Lattimer; M Kamijo; C Van Huysen; A A Sima; D A Greene
Journal:  Diabetologia       Date:  1993-07       Impact factor: 10.122

9.  Microangiopathy in human diabetic neuropathy: relationship between capillary abnormalities and the severity of neuropathy.

Authors:  R A Malik; P G Newrick; A K Sharma; A Jennings; A K Ah-See; T M Mayhew; J Jakubowski; A J Boulton; J D Ward
Journal:  Diabetologia       Date:  1989-02       Impact factor: 10.122

10.  The linked roles of nitric oxide, aldose reductase and, (Na+,K+)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat.

Authors:  M J Stevens; J Dananberg; E L Feldman; S A Lattimer; M Kamijo; T P Thomas; H Shindo; A A Sima; D A Greene
Journal:  J Clin Invest       Date:  1994-08       Impact factor: 14.808
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