Literature DB >> 6825794

Regulation of lactate dehydrogenase activity: reversible and isoenzyme-specific inhibition of the tetramerization process by peptides.

H Döbeli, G A Schoenenberger.   

Abstract

The transition of inactive lactic dehydrogenase (LDH) subunits to functional tetramers is controlled by 2 naturally-occurring peptides. One of these peptides inhibits the folding/association/activation process of H-LDH and the other peptide, the reconstitution of M-LDH, NADH and NAD+ are isoenzyme-specific antagonists of the 2 inhibitory peptides.

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Year:  1983        PMID： 6825794     DOI： 10.1007/bf01955304

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  Effect of coenzymes and temperature on the process of in vitro refolding and reassociation of lactic dehydrogenase isoenzymes.

Authors:  R Rudolph; I Heider; R Jaenicke
Journal:  Biochemistry       Date:  1977-12-13       Impact factor: 3.162

2.  Kinetics of reassociation and reactivation of pig-muscle lactic dehydrogenase after acid dissociation.

Authors:  R Rudolph; R Jaenicke
Journal:  Eur J Biochem       Date:  1976-04-01

3.  Reassociation and reactivation of lactic dehydrogenase from the unfolded subunits.

Authors:  R Jaenicke
Journal:  Eur J Biochem       Date:  1974-07-01

4.  Kinetics of in vitro reconstitution of oligomeric enzymes by cross-linking.

Authors:  R Hermann; R Rubolph; R Jaenicke
Journal:  Nature       Date:  1979-01-18       Impact factor: 49.962

5.  Analysis of the reconstitution of oligomeric enzymes by cross-linking with glutaraldehyde: kinetics of reassociation of lactic dehydrogenase.

Authors:  R Hermann; R Jaenicke; R Rudolph
Journal:  Biochemistry       Date:  1981-09-01       Impact factor: 3.162

6.  Reconstitution of lactic dehydrogenase after acid dissociation. The yield of reactivation is determined by conformational rearrangements of the dissociated monomers.

Authors:  G Zettlmeissl; R Rudolph; R Jaenicke
Journal:  Eur J Biochem       Date:  1981-12

7.  Limited proteolysis of porcine-muscle lactic dehydrogenase by thermolysin during reconstitution yields dimers.

Authors:  R Girg; R Rudolph; R Jaenicke
Journal:  Eur J Biochem       Date:  1981-10

8.  Peptides isolated from human liver with specific inhibitory effects on reassociation/reactivation of in vitro dissociated lactic dehydrogenase (LDH-M4 and -H4) isozymes.

Authors:  G A Schoenenberger; S Buser; L Cueni; H Döbeli; D Gillesen; W Lergier; G Schöttli; H J Tobler; K Wilson
Journal:  Regul Pept       Date:  1980-12

9.  Peptide inhibitors of lactic dehydrogenase (LDH). II. Isolation and characterization of peptides I and II.

Authors:  G A Schoenenberger; W E Wacker
Journal:  Biochemistry       Date:  1966-04       Impact factor: 3.162

10.  Isoenzyme specific inhibition of the reactivation of in vitro dissociated lactic dehydrogenase isoenzymes by two different peptides isolated from human liver.

Authors:  H Döbeli; H J Tobler; G A Schoenenberger
Journal:  Peptides       Date:  1982 Mar-Apr       Impact factor: 3.750
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  1 in total

1.  Could resistance to lactate accumulation contribute to the better swimming performance of Brycon amazonicus when compared to Colossoma macropomum?

Authors:  Marcio S Ferreira; Paulo H R Aride; Adalberto L Val
Journal:  PeerJ       Date:  2018-10-10       Impact factor: 2.984
  1 in total

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