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Literature DB >> 6824511

Free fatty acids in the pancreatitic arthritis syndrome.

P A Simkin, J D Brunzell, D Wisner, J J Fiechtner, J S Carlin, R F Willkens.

Abstract

Fat necrosis and arthritis occur in some individuals with pancreatitis. The intraarticular free fatty acid concentration was found to be markedly elevated in 2 patients with this pancreatitic arthritis syndrome. Injection of free fatty acids into rabbit knees reproduced the inflammatory synovial response including intracellular fat globules within leukocytes. Free fatty acids exceeding the available binding sites of albumin appear to mediate the extrapancreatic inflammatory manifestations of this syndrome.

Entities: Chemical Disease Species

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Year: 1983 PMID： 6824511 DOI： 10.1002/art.1780260202

Source DB: PubMed Journal: Arthritis Rheum ISSN： 0004-3591

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Cited

17 in total

1. Multiple subcutaneous inflammation, osteolysis, and polyarthritis.

Authors: Yasuhiko Takechi; Tetsuya Shinozaki; Toshio Fukuda; Kazuyoshi Asami; Takashi Yanagawa; Kenji Takagishi
Journal: Skeletal Radiol Date: 2010-06 Impact factor: 2.199

2. Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome: MRI features of intraosseous fat necrosis involving the feet and knees.

Authors: Dong Joo Kang; Sun Joo Lee; Hye Jung Choo; Minyoung Her; Hye Kyoung Yoon
Journal: Skeletal Radiol Date: 2016-12-07 Impact factor: 2.199

Free fatty acids in the pancreatitic arthritis syndrome.

1. Multiple subcutaneous inflammation, osteolysis, and polyarthritis.

2. Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome: MRI features of intraosseous fat necrosis involving the feet and knees.

3. Febrile polyarthritis and cutaneous nodules. An unusual presentation of a pancreatitis.

4. Immobilisation causes longlasting matrix changes both in the immobilised and contralateral joint cartilage.

Review 5. [Gastrointestinal tumors. Clinical manifestations of paraneoplastic rheumatic symptoms].

6. Traumatic chylous knee effusion.

7. Panniculitis in a patient presenting with a pancreatic tumour and polyarthritis: a case report.

8. Coexistence of arthritis, subcutaneous fat necrosis, and pseudocyst of pancreas.

9. Polyarthritis with chondronecrosis associated with osteonecrosis, panniculitis and pancreatitis.

10. Pancreatitis associated with pleural-mediastinal pseudocyst, panniculitis and polyarthritis.