Literature DB >> 6822504

gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini.

W D Henner, L O Rodriguez, S M Hecht, W A Haseltine.   

Abstract

Gamma irradiation of DNA in aqueous solution produces single strand breaks with two types of 3'-termini. These termini have been identified as a simple phosphoryl group and a glycolate moiety attached to the 3'-phosphoryl group via the 2"-OH of glycolic acid. Irradiation of 5'-end labeled poly(dG) produces compounds that comigrate with authentic 3',5'-dGDP and 2'-deoxyguanosine-3'-(phospho-2"-O-glycolic acid-5'-monophosphate by thin layer chromatography and polyacrylamide gel electrophoresis. Irradiation of poly(dGdC) followed by digestion to 3'-nucleotides produces 2'-deoxyguanosine-3'-(phospho-2"-O-glycolic acid). The presence of glycolate termini at some strand breaks may affect intracellular repair of these lesions.

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Year:  1983        PMID： 6822504

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  77 in total

1.  Clusters of S1 nuclease-hypersensitive sites induced in vivo by DNA damage.

Authors:  J Legault; A Tremblay; D Ramotar; M E Mirault
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

2.  Human HeLa cell enzymes that remove phosphoglycolate 3'-end groups from DNA.

Authors:  T A Winters; M Weinfeld; T J Jorgensen
Journal:  Nucleic Acids Res       Date:  1992-05-25       Impact factor: 16.971

3.  Photooxidation of d(TpG) by phthalocyanines and riboflavin. Isolation and characterization of dinucleoside monophosphates containing the 4R* and 4S* diastereoisomers of 4,8-dihydro-4-hydroxy-8-oxo-2'-deoxy-guanosine.

Authors:  G W Buchko; J Cadet; M Berger; J L Ravanat
Journal:  Nucleic Acids Res       Date:  1992-09-25       Impact factor: 16.971

4.  Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.

Authors:  Junko Murai; Shar-yin N Huang; Benu Brata Das; Thomas S Dexheimer; Shunichi Takeda; Yves Pommier
Journal:  J Biol Chem       Date:  2012-02-27       Impact factor: 5.157

5.  Patching and single-strand ligation in nonhomologous DNA end joining despite persistence of a closely opposed 3'-phosphoglycolate-terminated strand break.

Authors:  Rui-Zhe Zhou; Konstantin Akopiants; Lawrence F Povirk
Journal:  Radiat Res       Date:  2010-09       Impact factor: 2.841

Review 6.  A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.

Authors:  Karen H Almeida; Robert W Sobol
Journal:  DNA Repair (Amst)       Date:  2007-03-06

7.  In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation.

Authors:  Amy J Hawkins; Mark A Subler; Konstantin Akopiants; Jenny L Wiley; Shirley M Taylor; Ann C Rice; Jolene J Windle; Kristoffer Valerie; Lawrence F Povirk
Journal:  DNA Repair (Amst)       Date:  2009-02-10

Review 8.  Non-homologous DNA end joining and alternative pathways to double-strand break repair.

Authors:  Howard H Y Chang; Nicholas R Pannunzio; Noritaka Adachi; Michael R Lieber
Journal:  Nat Rev Mol Cell Biol       Date:  2017-05-17       Impact factor: 94.444

9.  The Mre11 nuclease is not required for 5' to 3' resection at multiple HO-induced double-strand breaks.

Authors:  Bertrand Llorente; Lorraine S Symington
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

10.  DNA strand breaking by the hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone.

Authors:  B Balasubramanian; W K Pogozelski; T D Tullius
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205
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